The present study was performed to compare serum concentrations of maternal and fetal angiogenic growth factors in IUGR (intrauterine growth restriction) and normal pregnancy at the time of delivery. VEGF (vascular endothelial growth factor), PlGF (placental growth factor), sFlt-1 (soluble fms-like tyrosine kinase 1), sKDR (soluble kinase domain receptor) and bFGF (basic fibroblast growth factor) were measured by ELISA in serum from a maternal peripheral vein, the umbilical vein and the umbilical arteries in 15 women with pregnancies complicated by IUGR and 16 controls (women with normal pregnancies). In IUGR, sFlt-1 was increased, and PlGF and sKDR were decreased, in both maternal serum and serum from the umbilical vein. Additionally, bFGF was increased in serum from the umbilical vein of women with pregnancies complicated by IUGR. No significant differences in growth factor concentrations between the groups were found in serum from the umbilical artery. In both groups, levels of VEGF were higher and levels of sFlt-1 were lower in serum from the umbilical vein and umbilical artery compared with maternal serum. PlGF levels were found to be lower in serum from the umbilical vein compared with maternal serum in both groups, whereas PlGF levels in serum from the umbilical artery were significantly lower only in the control group. These findings suggest an imbalance of angiogenic and anti-angiogenic factors in IUGR, with formation of an anti-angiogenic state in maternal and, to a lesser extent, umbilical vein blood. The placenta appears to play a central role in the release of sFlt-1 into maternal and umbilical blood. Umbilical artery blood was unaffected in IUGR, indicating that the fetus does not contribute to changes in angiogenic growth factor concentrations.
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January 2007
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Research Article|
December 01 2006
Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction
Wenzel Wallner;
Wenzel Wallner
*Department of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen, Germany
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Ruth Sengenberger;
Ruth Sengenberger
*Department of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen, Germany
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Reiner Strick;
Reiner Strick
*Department of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen, Germany
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Pamela L. Strissel;
Pamela L. Strissel
*Department of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen, Germany
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Britta Meurer;
Britta Meurer
*Department of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen, Germany
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Matthias W. Beckmann;
Matthias W. Beckmann
*Department of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen, Germany
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Dietmar Schlembach
*Department of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen, Germany
†Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
Correspondence: Dr Dietmar Schlembach, at the Department of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria (email [email protected]).
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Publisher: Portland Press Ltd
Received:
June 22 2006
Revision Received:
August 10 2006
Accepted:
August 24 2006
Accepted Manuscript online:
August 24 2006
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2007
Clin Sci (Lond) (2007) 112 (1): 51–57.
Article history
Received:
June 22 2006
Revision Received:
August 10 2006
Accepted:
August 24 2006
Accepted Manuscript online:
August 24 2006
Citation
Wenzel Wallner, Ruth Sengenberger, Reiner Strick, Pamela L. Strissel, Britta Meurer, Matthias W. Beckmann, Dietmar Schlembach; Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction. Clin Sci (Lond) 1 January 2007; 112 (1): 51–57. doi: https://doi.org/10.1042/CS20060161
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