Oestrogen therapy is the gold standard treatment for hot flushes/night sweats, but it and oestrogen/progestin are not suitable for all women. MPA (medroxyprogesterone acetate) reduces hot flushes, but its effectiveness compared with oestrogen is unknown. In the present study, oral oestrogen [CEE (conjugated equine oestrogen)] and MPA were compared for their effects on hot flushes in a planned analysis of a secondary outcome for a 1-year randomized double-blind parallel group controlled trial in an urban academic medical centre. Participants were healthy menstruating women prior to hysterectomy/ovariectomy for benign disease. A total of 41 women {age, 45 (5) years [value is mean (S.D.)]} were enrolled; 38 women were included in this analysis of daily identical capsules containing CEE (0.6 mg/day) or MPA (10 mg/day). Demographic variables did not differ at baseline. Daily data provided the number of night and day flushes compared by group. The vasomotor symptom day-to-day intensity change was assessed by therapy assignment. Hot flushes/night sweats were well controlled in both groups, one occurred on average every third day and every fourth night. Mean/day daytime occurrences were 0.363 and 0.187 with CEE and MPA respectively, but were not significantly different (P=0.156). Night sweats also did not differ significantly (P=0.766). Therapies were statistically equivalent (within one event/24 h) in the control of vasomotor symptoms. Day-to-day hot flush intensity decreased with MPA and tended to remain stable with CEE (P<0.001). In conclusion, this analysis demonstrates that MPA and CEE are equivalent and effective in the control of the number of hot flushes/night sweats immediately following premenopausal ovariectomy.
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May 2007
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Research Article|
April 12 2007
Medroxyprogesterone and conjugated oestrogen are equivalent for hot flushes: a 1-year randomized double-blind trial following premenopausal ovariectomy
Jerilynn C. Prior;
*Centre for Menstrual Cycle and Ovulation Research, Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada V5Z 1M9
Correspondence: Professor Jerilynn C. Prior (email [email protected]).
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Jason D. Nielsen;
Jason D. Nielsen
†Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
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Christine L. Hitchcock;
Christine L. Hitchcock
*Centre for Menstrual Cycle and Ovulation Research, Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada V5Z 1M9
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Lucy A. Williams;
Lucy A. Williams
‡The Margaret Smith Menopause Unit, Menopause Service, King Edward Memorial Hospital for Women, Perth, WA 6008, Australia
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Yvette M. Vigna;
Yvette M. Vigna
*Centre for Menstrual Cycle and Ovulation Research, Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada V5Z 1M9
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Charmaine B. Dean
Charmaine B. Dean
†Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
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Publisher: Portland Press Ltd
Received:
August 21 2006
Revision Received:
December 19 2006
Accepted:
January 10 2007
Accepted Manuscript online:
January 10 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2007
Clin Sci (Lond) (2007) 112 (10): 517–525.
Article history
Received:
August 21 2006
Revision Received:
December 19 2006
Accepted:
January 10 2007
Accepted Manuscript online:
January 10 2007
Citation
Jerilynn C. Prior, Jason D. Nielsen, Christine L. Hitchcock, Lucy A. Williams, Yvette M. Vigna, Charmaine B. Dean; Medroxyprogesterone and conjugated oestrogen are equivalent for hot flushes: a 1-year randomized double-blind trial following premenopausal ovariectomy. Clin Sci (Lond) 1 May 2007; 112 (10): 517–525. doi: https://doi.org/10.1042/CS20060228
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