Engaging in regular physical activity reduces the risk of developing CVD (cardiovascular disease), but it is not certain to what degree this may be due to the anti-inflammatory effects of exercise. Following acute exercise, there is a transient increase in circulating levels of anti-inflammatory cytokines, whereas chronic exercise reduces basal levels of pro-inflammatory cytokines. Exercise training also induces the expression of antioxidant and anti-inflammatory mediators in the vascular wall that may directly inhibit the development of atherosclerosis. Limited studies in humans and more comprehensive assessments in animal models have confirmed that exercise is atheroprotective and helped identify a number of the mechanisms to explain these effects. This review explores the relationship between systemic and vascular wall inflammation and the role that the anti-inflammatory effects of exercise have on the development and progression of CVD.
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Review Article| May 01 2007
Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?
Kenneth R. Wilund
1Cardiovascular Research Laboratory, Department of Kinesiology and Community Health, University of Illinois, 906 S. Goodwin Avenue, Urbana, IL 61801, U.S.A.
Correspondence: Dr Kenneth R. Wilund (email firstname.lastname@example.org).
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Publisher: Portland Press Ltd
Received: December 19 2006
Revision Received: January 18 2007
Accepted: January 18 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2007 The Biochemical Society
Kenneth R. Wilund; Is the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?. Clin Sci (Lond) 1 June 2007; 112 (11): 543–555. doi: https://doi.org/10.1042/CS20060368
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