Differences in the diagnostic value of a variety of definitions of negative T waves for HCM (hypertrophic cardiomyopathy) have not yet been clarified, resulting in a number of definitions being applied in previous studies. The aim of the present study was to determine the most accurate diagnostic definition of negative T waves for HCM in genotyped populations. Electrocardiographic and echocardiographic findings were analysed in 161 genotyped subjects (97 carriers and 64 non-carriers). We applied three different criteria that have been used in previous studies: Criterion 1, negative T wave >10 mm in depth in any leads; Criterion 2, negative T wave >3 mm in depth in at least two leads; and Criterion 3, negative T wave >1 mm in depth in at least two leads. Of the three criteria, Criterion 3 had the highest sensitivity (43% compared with 5 and 26% in Criterion 1 and Criterion 2 respectively; P<0.0001) and retained a specificity of 95%, resulting in the highest accuracy. In comparison with abnormal Q waves, negative T waves for Criterion 3 had a lower sensitivity in detecting carriers without LVH (left ventricular hypertrophy) (12.9% for negative T waves compared with 22.6% for abnormal Q waves). On the other hand, in detecting carriers with LVH, the sensitivity of negative T waves increased in a stepwise direction with the increasing extent of LVH (P<0.001), whereas there was less association between the sensitivity of abnormal Q waves and the extent of LVH. In conclusion, Criterion 3 for negative T waves may be the most accurate definition of HCM based on genetic diagnoses. Negative T waves may show different diagnostic value according to the different criteria and phenotypes in genotyped populations with HCM.
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Research Article|
May 01 2007
Differences in the diagnostic value of various criteria of negative T waves for hypertrophic cardiomyopathy based on a molecular genetic diagnosis
Tetsuo Konno;
Tetsuo Konno
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
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Noboru Fujino;
Noboru Fujino
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
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Kenshi Hayashi;
Kenshi Hayashi
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
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Katsuharu Uchiyama;
Katsuharu Uchiyama
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
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Eiichi Masuta;
Eiichi Masuta
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
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Hiromasa Katoh;
Hiromasa Katoh
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
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Yuichiro Sakamoto;
Yuichiro Sakamoto
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
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Toshinari Tsubokawa;
Toshinari Tsubokawa
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
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Hidekazu Ino;
Hidekazu Ino
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
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Masakazu Yamagishi
1Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa 920-8640, Japan
Correspondence: Dr Masakazu Yamagishi (email [email protected]).
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Publisher: Portland Press Ltd
Received:
October 16 2006
Revision Received:
January 24 2007
Accepted:
January 31 2007
Accepted Manuscript online:
January 31 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2007 Biochemical Society
2007
Clin Sci (Lond) (2007) 112 (11): 577–582.
Article history
Received:
October 16 2006
Revision Received:
January 24 2007
Accepted:
January 31 2007
Accepted Manuscript online:
January 31 2007
Citation
Tetsuo Konno, Noboru Fujino, Kenshi Hayashi, Katsuharu Uchiyama, Eiichi Masuta, Hiromasa Katoh, Yuichiro Sakamoto, Toshinari Tsubokawa, Hidekazu Ino, Masakazu Yamagishi; Differences in the diagnostic value of various criteria of negative T waves for hypertrophic cardiomyopathy based on a molecular genetic diagnosis. Clin Sci (Lond) 1 June 2007; 112 (11): 577–582. doi: https://doi.org/10.1042/CS20060293
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