The aim of the present study was to delineate the mechanism(s) responsible for the increased secretion of VLDL (very-low-density lipoprotein) particles in patients with FCH (familial combined hyperlipidaemia). In 194 young adults (<25 years of age) recruited from families with FCH, we investigated how plasma lipids, (apo)lipoproteins and BMI (body mass index) varied with age. Furthermore, we performed a 5-year follow-up study of clinical and biochemical characteristics of a subset of this population (n=85) stratified by apoB (apolipoprotein B) levels (below or above the 75th percentile adjusted for age and gender). Plasma apoB concentration (r=0.45, P<0.0001), triacylglycerol (triglyceride) concentration (r=0.45, P<0.0001), LDL (low-density lipoprotein) subfraction profile (r=−0.46, P<0.0001) and BMI (r=0.51, P<0.0001) were significantly associated with age. Plasma apoB concentration in the hyperapoB group was already elevated at a young age, whereas other characteristics of FCH, as observed in adults, including triacylglycerol levels >1.5 mmol/l and/or small-dense LDL, were observed only sporadically. After the 5-year follow-up, BMI increased in both groups, and this increase was associated with changes in apoB (r=0.27, P<0.05), triacylglycerol (r=0.30, P<0.01), VLDL cholesterol (r=0.22, P<0.05), VLDL triacylglycerol (r=0.25, P<0.05) and high-density lipoprotein cholesterol (r=−0.27, P<0.05). In conclusion, we have found indirect evidence of a primary, presumably genetically determined, increase in plasma apoB concentration occurring early in life of offspring from families with FCH. However, aging-related post-maturation increases in adipose tissue mass also appear to contribute to an aggravation and/or modulation of this genetically determined apoB overproduction.
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January 2007
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Research Article|
December 11 2006
Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia
Ewoud ter Avest;
*Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
Correspondence:Dr Ewoud ter Avest (email [email protected]).
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Allan D. Sniderman;
Allan D. Sniderman
†Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University, Montreal, Quebec, Canada
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Sebastian J. H. Bredie;
Sebastian J. H. Bredie
*Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
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Albert Wiegman;
Albert Wiegman
‡Department of Paediatrics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
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Anton F. H. Stalenhoef;
Anton F. H. Stalenhoef
*Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
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Jacqueline de Graaf
Jacqueline de Graaf
*Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
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Publisher: Portland Press Ltd
Received:
August 23 2006
Revision Received:
October 20 2006
Accepted:
October 23 2006
Accepted Manuscript online:
October 23 2006
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2007
Clin Sci (Lond) (2007) 112 (2): 131–139.
Article history
Received:
August 23 2006
Revision Received:
October 20 2006
Accepted:
October 23 2006
Accepted Manuscript online:
October 23 2006
Citation
Ewoud ter Avest, Allan D. Sniderman, Sebastian J. H. Bredie, Albert Wiegman, Anton F. H. Stalenhoef, Jacqueline de Graaf; Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia. Clin Sci (Lond) 1 January 2007; 112 (2): 131–139. doi: https://doi.org/10.1042/CS20060234
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