Minimal model analysis of glucose and insulin data from an IVGTT (intravenous glucose tolerance test) is widely used to estimate insulin sensitivity; however, the use of the model often requires intervention by a trained operator and some problems can occur in the estimation of model parameters. In the present study, a new method for minimal model analysis, termed GAMMOD, was developed based on genetic algorithms for the estimation of model parameters. Such an algorithm does not require the fixing of initial values for the parameters (that may lead to unreliable estimates). Our method also implements an automated weighting scheme not requiring manual intervention of the operator, thus improving the usability of the model. We studied a group of 170 women with a history of previous gestational diabetes. Results obtained by GAMMOD were compared with those obtained by MINMOD (a traditional gradient-based algorithm for minimal model analysis). Insulin sensitivity by GAMMOD was (3.86±0.19) compared with (4.33±0.20)×10−4 μ-units·ml−1·min−1 by MINMOD; glucose effectiveness was 0.0236±0.0005 compared with 0.0229±0.0005 min−1 respectively. The difference in the estimation by the two methods was within the precision expected for such metabolic parameters and is probably of no clinical relevance. Moreover, both the coefficient of variation of the estimated parameters and the error of fit were generally lower in GAMMOD, despite the fact that it does not require manual intervention. In conclusion, the GAMMOD approach for parameter estimation in the minimal model provides a reliable estimation of the model parameters and improves the usability of the model, thus facilitating its further use and application in a clinical context.
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February 2007
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Research Article|
January 17 2007
Improved usability of the minimal model of insulin sensitivity based on an automated approach and genetic algorithms for parameter estimation
Umberto Morbiducci;
Umberto Morbiducci
*Department of Mechanics, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
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Giacomo Di Benedetto;
Giacomo Di Benedetto
†Department of Mechanical Technology and Managerial Engineering, University of Palermo, Viale delle Scienze, 90128 Palermo, Italy
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Alexandra Kautzky-Willer;
Alexandra Kautzky-Willer
‡Department of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
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Giovanni Pacini;
Giovanni Pacini
§Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Corso Stati Uniti 4, 35127 Padua, Italy
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Andrea Tura
§Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Corso Stati Uniti 4, 35127 Padua, Italy
Correspondence: Dr Andrea Tura (email [email protected]).
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Publisher: Portland Press Ltd
Received:
August 01 2006
Revision Received:
September 07 2006
Accepted:
September 11 2006
Accepted Manuscript online:
September 11 2006
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2007
Clin Sci (Lond) (2007) 112 (4): 257–263.
Article history
Received:
August 01 2006
Revision Received:
September 07 2006
Accepted:
September 11 2006
Accepted Manuscript online:
September 11 2006
Citation
Umberto Morbiducci, Giacomo Di Benedetto, Alexandra Kautzky-Willer, Giovanni Pacini, Andrea Tura; Improved usability of the minimal model of insulin sensitivity based on an automated approach and genetic algorithms for parameter estimation. Clin Sci (Lond) 1 February 2007; 112 (4): 257–263. doi: https://doi.org/10.1042/CS20060203
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