The critical phase during cardiosurgical procedures is weaning the diseased heart from the ECC (extracorporeal circulation). Post-ischaemic heart failure sometimes requires the administration of inotropic and/or vasconstrictive agents. The natriuretic peptides influence pre- and after-load through their natriuretic, diuretic and vasodilating actions. To date, there are only a few reports describing the therapeutic effect of BNP (brain natriuretic peptide) administration during cardiosurgical procedures. The aim of the present study was to evaluate the effect of BNP administration following ECC in an animal model. Surgery was performed on 20 pigs using ECC. A 30-min ischaemic episode was simulated. Following de-clamping, BNP was administered to the BNP group (n=10) by an i.v. (intravenous) bolus at 0.3 μg·kg−1 of body weight·min−1, followed by an infusion at a rate of 0.015 μg·kg−1 of body weight·min−1 for 60 min. The animals in the control group (n=10) received a saline solution instead of BNP. Haemodynamic and clinical chemistry parameters as well as the amount of catecholamines that were required were measured. All of the animals in the BNP group had a significantly better cardiac output and cardiac index at the end of the experiment. Seven out of 10 animals from the control group required catecholamines, whereas only one animal from the BNP group did. Creatine kinase levels were significantly lower in the BNP group. Systemic vascular resistance was markedly lower in the BNP group. In conclusion, administration of BNP is highly effective in treating post-ischaemic heart failure following ECC. Haemodynamics are greatly improved, and there is almost no need for pharmacological support.
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March 2007
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Research Article|
February 01 2007
Administration of brain natriuretic peptide improves cardiac function following operations using extracorporeal circulation in an animal model
Dorothee H. L. Bail;
1Department of Thoracic, Cardiac and Vascular Surgery, University of Tübingen, Hoppe-Seyler Str. 3, D-72076 Tübingen, Germany
Correspondence: Dr Dorothee H. L. Bail (email [email protected]).
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Volker Steger;
Volker Steger
1Department of Thoracic, Cardiac and Vascular Surgery, University of Tübingen, Hoppe-Seyler Str. 3, D-72076 Tübingen, Germany
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Uli Heinzelmann;
Uli Heinzelmann
1Department of Thoracic, Cardiac and Vascular Surgery, University of Tübingen, Hoppe-Seyler Str. 3, D-72076 Tübingen, Germany
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Sandra Schiller;
Sandra Schiller
1Department of Thoracic, Cardiac and Vascular Surgery, University of Tübingen, Hoppe-Seyler Str. 3, D-72076 Tübingen, Germany
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Anita I. Geim;
Anita I. Geim
1Department of Thoracic, Cardiac and Vascular Surgery, University of Tübingen, Hoppe-Seyler Str. 3, D-72076 Tübingen, Germany
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Benjamin Brüllmann;
Benjamin Brüllmann
1Department of Thoracic, Cardiac and Vascular Surgery, University of Tübingen, Hoppe-Seyler Str. 3, D-72076 Tübingen, Germany
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Gerhard Ziemer
Gerhard Ziemer
1Department of Thoracic, Cardiac and Vascular Surgery, University of Tübingen, Hoppe-Seyler Str. 3, D-72076 Tübingen, Germany
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Publisher: Portland Press Ltd
Received:
June 02 2006
Revision Received:
October 18 2006
Accepted:
October 31 2006
Accepted Manuscript online:
October 31 2006
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2007
Clin Sci (Lond) (2007) 112 (5): 315–324.
Article history
Received:
June 02 2006
Revision Received:
October 18 2006
Accepted:
October 31 2006
Accepted Manuscript online:
October 31 2006
Citation
Dorothee H. L. Bail, Volker Steger, Uli Heinzelmann, Sandra Schiller, Anita I. Geim, Benjamin Brüllmann, Gerhard Ziemer; Administration of brain natriuretic peptide improves cardiac function following operations using extracorporeal circulation in an animal model. Clin Sci (Lond) 1 March 2007; 112 (5): 315–324. doi: https://doi.org/10.1042/CS20060136
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