The glomerular filtration barrier consists of the fenestrated endothelium, the glomerular basement membrane and the terminally differentiated visceral epithelial cells known as podocytes. It is now widely accepted that damage to, or originating within, the podocytes is a key event that initiates progression towards sclerosis in many glomerular diseases. A wide variety of strategies have been employed by investigators from many scientific disciplines to study the podocyte. Although invaluable insights have accrued from conventional approaches, including cell culture and biochemical-based methods, many renal researchers continue to rely upon the mouse to address the form and function of the podocyte. This review summarizes how genetic manipulation in the mouse has advanced our understanding of the podocyte in relation to the maintenance of the glomerular filtration barrier in health and disease.
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March 2007
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Review Article|
February 12 2007
The podocyte in health and disease: insights from the mouse
Jean-Louis R. Michaud
;
Jean-Louis R. Michaud
*Kidney Research Centre and Molecular Medicine Program, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
†Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
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Chris R. J. Kennedy
*Kidney Research Centre and Molecular Medicine Program, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
†Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
Correspondence: Dr Chris R. J. Kennedy, at Kidney Research Centre and Molecular Medicine Program, Ottawa Health Research Institute, Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada K1H 8M5 (email ckennedy@uottawa.ca).
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Clin Sci (Lond) (2007) 112 (6): 325–335.
Article history
Received:
June 08 2006
Revision Received:
September 07 2006
Accepted:
October 10 2006
Citation
Jean-Louis R. Michaud, Chris R. J. Kennedy; The podocyte in health and disease: insights from the mouse. Clin Sci (Lond) 1 March 2007; 112 (6): 325–335. doi: https://doi.org/10.1042/CS20060143
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