It has been suggested that Type 2 diabetes may, in part, be precipitated or accelerated by an acute-phase reaction as part of the innate immune response, in which large amounts of cytokines are released from adipose tissue, creating a low-grade inflammatory milieu. There is also firm evidence that atherosclerosis is an immune-mediated inflammatory disease. Therefore it is reasonable to imply that low-grade inflammation is an important pathogenetic factor in atherosclerosis and cardiovascular events in patients with Type 2 diabetes. Over the last few years, there have been a lot of promising clinical markers proposed to link inflammation and atherosclerosis. Of these markers, hs-CRP (high-sensitivity C-reactive protein) might be a prognostic marker for further cardiovascular events, although this has been refuted recently. In this issue of Clinical Science, Castoldi and co-workers have demonstrated that, in patients with Type 2 diabetes categorized into low (<1.0 mg/l), medium (1.0–3.0 mg/l) and high (>3.0 mg/l) hs-CRP groups, serum levels of hs-CRP correlated with lipopolysaccharide-stimulated release of interleukin-1β and interleukin-6 in whole blood. This finding may indicate that low-grade inflammatory activity might influence cytokine production in these patients.
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July 2007
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Commentary|
June 13 2007
C-reactive protein: a marker or a player?
Thomas Nyström
1Department of Internal Medicine, Karolinska Institutet, Stockholm South Hospital, SE-118 83 Stockholm, Sweden
Correspondence: Dr Thomas Nyström (email [email protected]).
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Publisher: Portland Press Ltd
Received:
April 04 2007
Revision Received:
April 19 2007
Accepted:
April 23 2007
Accepted Manuscript online:
April 23 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2007 Biochemical Society
2007
Clin Sci (Lond) (2007) 113 (2): 79–81.
Article history
Received:
April 04 2007
Revision Received:
April 19 2007
Accepted:
April 23 2007
Accepted Manuscript online:
April 23 2007
Citation
Thomas Nyström; C-reactive protein: a marker or a player?. Clin Sci (Lond) 1 July 2007; 113 (2): 79–81. doi: https://doi.org/10.1042/CS20070121
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