Staging criteria for COPD (chronic obstructive pulmonary disease) include symptoms and lung function parameters, but the role of reduced inspiratory muscle strength related to disease severity remains unclear. Therefore the present study tested whether inspiratory muscle strength is reduced in COPD and is related to disease severity according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria and assessed its clinical impact. PImax (maximal inspiratory mouth occlusion pressure), SnPna (sniff nasal pressure) and TwPmo (twitch mouth pressure) following bilateral anterior magnetic phrenic nerve stimulation were assessed in 33 COPD patients (8 GOLD0, 6 GOLDI, 6 GOLDII, 7 GOLDIII and 6 GOLDIV) and in 28 matched controls. Furthermore, all participants performed a standardized 6 min walking test. In comparison with controls, PImax (11.6±2.5 compared with 7.3±3.0 kPa; P<0.001), SnPna (9.7±2.5 compared with 6.9±3.3 kPa; P<0.001) and TwPmo (1.6±0.6 compared with 0.8±0.4 kPa; P<0.001) were markedly lower in COPD patients. TwPmo decreased with increasing COPD stage. TwPmo was correlated with walking distance (r=0.75; P<0.001), dyspnoea (r=−0.61; P<0.001) and blood gas values following exercise (r>0.57; P<0.001). Inspiratory muscle strength, as reliably assessed by TwPmo, decreased with increasing severity of COPD and should be considered as an important factor in rating disease severity and to reflect burden in COPD.
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September 2007
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Research Article|
August 01 2007
Inspiratory muscle strength in chronic obstructive pulmonary disease depending on disease severity
Hans-Joachim Kabitz;
Hans-Joachim Kabitz
1
1Department of Pneumology, University Hospital Freiburg, Killianstrasse 5, 79106 Freiburg, Germany
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Stephan Walterspacher;
Stephan Walterspacher
1
1Department of Pneumology, University Hospital Freiburg, Killianstrasse 5, 79106 Freiburg, Germany
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David Walker;
David Walker
1Department of Pneumology, University Hospital Freiburg, Killianstrasse 5, 79106 Freiburg, Germany
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Wolfram Windisch
1Department of Pneumology, University Hospital Freiburg, Killianstrasse 5, 79106 Freiburg, Germany
Correspondence: Dr Wolfram Windisch (email [email protected]).
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Publisher: Portland Press Ltd
Received:
December 14 2006
Revision Received:
March 15 2007
Accepted:
March 29 2007
Accepted Manuscript online:
March 29 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2007 The Biochemical Society
2007
Clin Sci (Lond) (2007) 113 (5): 243–249.
Article history
Received:
December 14 2006
Revision Received:
March 15 2007
Accepted:
March 29 2007
Accepted Manuscript online:
March 29 2007
Citation
Hans-Joachim Kabitz, Stephan Walterspacher, David Walker, Wolfram Windisch; Inspiratory muscle strength in chronic obstructive pulmonary disease depending on disease severity. Clin Sci (Lond) 1 September 2007; 113 (5): 243–249. doi: https://doi.org/10.1042/CS20060362
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