There is an unsettled debate about the role of magnesium as a ‘chronic regulator’ of biological functions, as opposed to the well-known role for calcium as an ‘acute regulator’. New and old findings appear to delineate an increasingly complex and important role for magnesium in many cellular functions. This review summarizes the available evidence for a link between the regulation of intracellular magnesium availability and the control of cell growth, energy metabolism and death, both in healthy and diseased conditions. A comprehensive view is precluded by technical difficulties in tracing magnesium within a multicompartment and dynamic environment like the cell; nevertheless, the last few years has witnessed encouraging progress towards a better characterization of magnesium transport and its storage or mobilization inside the cell. The latest findings pave the road towards a new and deeper appreciation of magnesium homoeostasis and its role in the regulation of essential cell functions.
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January 2008
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Review Article|
November 30 2007
Cell (patho)physiology of magnesium
Federica I. Wolf;
1Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facoltà di Medicina, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Roma, Italy
Correspondence: Professor Federica I. Wolf (email [email protected]).
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Valentina Trapani
Valentina Trapani
1Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facoltà di Medicina, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Roma, Italy
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Publisher: Portland Press Ltd
Received:
April 17 2007
Revision Received:
June 12 2007
Accepted:
June 26 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (1): 27–35.
Article history
Received:
April 17 2007
Revision Received:
June 12 2007
Accepted:
June 26 2007
Citation
Federica I. Wolf, Valentina Trapani; Cell (patho)physiology of magnesium. Clin Sci (Lond) 1 January 2008; 114 (1): 27–35. doi: https://doi.org/10.1042/CS20070129
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