The aim of the present study was to investigate whether imatinib affects insulin sensitivity and glucose disposal in HF (high-fat)-fed rats. Sprague–Dawley rats were fed either a standard pelleted rat food (low-fat diet) or an HF diet (60% fat) for 8 weeks. During the last 10 days of the HF diet regime, rats received saline alone or imatinib (50 or 100 mg/kg of body weight) daily by gavage. The higher dose of imatinib resulted in a decreased psoas fat pad weight in the HF-treated rats. Under euglycaemic hyperinsulinaemic clamp conditions, HF-fed rats exhibited increased insulin concentrations and decreased glucose disposal. The lower (50 mg/kg of body weight), but not the higher (100 mg/kg of body weight), dose of imatinib normalized insulin sensitivity and glucose disposal without affecting glucose metabolism in low-fat-fed rats. Hepatic glucose production at both fasting and hyperinsulinaemic conditions was only weakly affected by imatinib. We conclude that a moderate dose of imatinib efficiently counteracts HF-induced peripheral insulin resistance, and that further studies on the mechanisms by which imatinib increases insulin action in muscle and fat tissues might generate novel strategies for the treatment of Type 2 diabetes.
Skip Nav Destination
Article navigation
January 2008
-
Cover Image
Cover Image
- PDF Icon PDF LinkTable of Contents
Research Article|
November 30 2007
Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet
Robert Hägerkvist;
Robert Hägerkvist
1Department of Medical Cell Biology, Uppsala University, S-75123 Uppsala, Sweden
Search for other works by this author on:
Leif Jansson;
Leif Jansson
1Department of Medical Cell Biology, Uppsala University, S-75123 Uppsala, Sweden
Search for other works by this author on:
Nils Welsh
1Department of Medical Cell Biology, Uppsala University, S-75123 Uppsala, Sweden
Correspondence: Dr Nils Welsh (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
April 04 2007
Revision Received:
July 20 2007
Accepted:
July 25 2007
Accepted Manuscript online:
July 25 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (1): 65–71.
Article history
Received:
April 04 2007
Revision Received:
July 20 2007
Accepted:
July 25 2007
Accepted Manuscript online:
July 25 2007
Citation
Robert Hägerkvist, Leif Jansson, Nils Welsh; Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet. Clin Sci (Lond) 1 January 2008; 114 (1): 65–71. doi: https://doi.org/10.1042/CS20070122
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |