Chronic fish oil intervention had been shown to have a positive impact on endothelial function. Although high-fat meals have often been associated with a loss of postprandial vascular reactivity, studies examining the effects of fish oil fatty acids on vascular function in the postprandial phase are limited. The aim of the present study was to examine the impact of the addition of fish oil fatty acids to a standard test meal on postprandial vascular reactivity. A total of 25 men received in a random order either a placebo oil meal (40 g of mixed fat; fatty acid profile representative of the U.K. diet) or a fish oil meal (31 g of mixed fat and 9 g of fish oil) on two occasions. Vascular reactivity was measured at baseline (0 h) and 4 h after the meal by laser Doppler iontophoresis, and blood samples were taken for the measurement of plasma lipids, total nitrite, glucose and insulin. eNOS (endothelial NO synthase) and NADPH oxidase gene expression were determined in endothelial cells after incubation with TRLs (triacylglycerol-rich lipoproteins) isolated from the plasma samples taken at 4 h. Compared with baseline, sodium nitroprusside (an endothelium-independent vasodilator)-induced reactivity (P=0.024) and plasma nitrite levels (P=0.001) were increased after the fish oil meal. In endothelial cells, postprandial TRLs isolated after the fish oil meal increased eNOS and decreased NADPH oxidase gene expression compared with TRLs isolated following the placebo oil meal (P≤0.03). In conclusion, meal fatty acids appear to be an important determinant of vascular reactivity, with fish oils significantly improving postprandial endothelium-independent vasodilation.
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June 2008
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Research Article|
May 01 2008
Fish oil fatty acids improve postprandial vascular reactivity in healthy men
Christopher K. Armah;
Christopher K. Armah
1Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading RG6 6AP, U.K.
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Kim G. Jackson;
1Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading RG6 6AP, U.K.
Correspondence: Dr Kim Jackson (email [email protected]).
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Izzy Doman;
Izzy Doman
1Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading RG6 6AP, U.K.
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Lewis James;
Lewis James
1Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading RG6 6AP, U.K.
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Farah Cheghani;
Farah Cheghani
1Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading RG6 6AP, U.K.
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Anne M. Minihane
Anne M. Minihane
1Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading RG6 6AP, U.K.
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Publisher: Portland Press Ltd
Received:
August 02 2007
Revision Received:
November 16 2007
Accepted:
December 03 2007
Accepted Manuscript online:
December 03 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (11): 679–686.
Article history
Received:
August 02 2007
Revision Received:
November 16 2007
Accepted:
December 03 2007
Accepted Manuscript online:
December 03 2007
Citation
Christopher K. Armah, Kim G. Jackson, Izzy Doman, Lewis James, Farah Cheghani, Anne M. Minihane; Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clin Sci (Lond) 1 June 2008; 114 (11): 679–686. doi: https://doi.org/10.1042/CS20070277
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