INSR (insulin-resistance syndrome) affects 25% of the Australian population and is associated with increased cardiovascular risk. In the present study, we postulated that early cardiovascular changes in these individuals may be associated with an activated RAS (renin–angiotensin system). We studied 26 subjects: 13 with INSR [waist circumference, 99±6 cm; HOMA (homoeostasis model assessment) score, 2.5±0.3] and 13 NCs (normals controls; waist circumference, 77±2 cm; HOMA score, 1.4±0.2). All received intravenous GTN (glyceryl trinitrate; 10, 20 and 40 μg/min), L-NMMA (NG-monomethyl-L-arginine; 3 mg/kg of body weight), AngII (angiotensin II; 8 and 16 ng/min), the selective AT2R (AngII type 2 receptor) inhibitor PD123319 (10 and 20 μg/min) and AngII (16 ng/min)+PD123319 (20 μg/min). At the end of each infusion, arterial stiffness indices [SI (stiffness index) and RI (reflection index)] and haemodynamic parameters were measured. There was a significantly higher RI response to AngII (P=0.0004 for both 8 and 16 ng/min doses) and to PD123319 (P=0.004 and P=0.03 for 10 and 20 μg/min doses respectively) in subjects with INSR compared with NCs. Co-infusion of AngII and PD123319 did not lead to additive changes in RI. RI responses to L-NMMA and GTN were not significantly different in both groups. No significant differences in SI and haemodynamic responses were detected. In conclusion, AT1R (AngII type 1 receptor) and AT2R activity produce arterial stiffness changes in subjects with INSR. Evidence of increased AT1R- and AT2R-mediated responses in small-to-medium-sized arteries in INSR was found, and may play an early role in the pathogenesis of vascular changes in INSR before haemodynamic changes become apparent.
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January 2008
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Research Article|
December 11 2007
Arterial stiffness and haemodynamic response to vasoactive medication in subjects with insulin-resistance syndrome
Divina G. Brillante;
Divina G. Brillante
*Department of Medicine, St George Clinical School, University of New South Wales, Chapel Street, Kogarah, NSW 2217, Australia
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Anthony J. O'Sullivan;
Anthony J. O'Sullivan
*Department of Medicine, St George Clinical School, University of New South Wales, Chapel Street, Kogarah, NSW 2217, Australia
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Martina T. Johnstone;
Martina T. Johnstone
†Department of Nuclear Medicine, St George Hospital, Gray Street, Kogarah, NSW 2217, Australia
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Laurence G. Howes
‡Department of Cardiology, Bond University Medical Schools, Gold Coast Hospital, Nerang St, Southport, QLD 4215, Australia
§Department of Pharmacology and Therapeutics, Griffith and Bond University Medical Schools, Gold Coast Hospital, Nerang St, Southport, QLD 4215, Australia
Correspondence: Professor Laurence G. Howes (email [email protected]).
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Publisher: Portland Press Ltd
Received:
April 17 2007
Revision Received:
July 25 2007
Accepted:
August 08 2007
Accepted Manuscript online:
August 08 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (2): 139–147.
Article history
Received:
April 17 2007
Revision Received:
July 25 2007
Accepted:
August 08 2007
Accepted Manuscript online:
August 08 2007
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Citation
Divina G. Brillante, Anthony J. O'Sullivan, Martina T. Johnstone, Laurence G. Howes; Arterial stiffness and haemodynamic response to vasoactive medication in subjects with insulin-resistance syndrome. Clin Sci (Lond) 1 January 2008; 114 (2): 139–147. doi: https://doi.org/10.1042/CS20070132
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