There has been increasing excitement over the last few years with the suggestion that exogenous stem cells may offer new treatment options for a wide range of diseases. Within respiratory medicine, these cells have been shown to have the ability to differentiate and function as both airway and lung parenchyma epithelial cells in both in vitro and increasingly in vivo experiments. The hypothesis is that these cells may actively seek out damaged tissue to assist in the local repair, and the hope is that their use will open up new cellular and genetic treatment modalities. Such is the promise of these cells that they are being rushed from the benchside to the bedside with the commencement of early clinical trials. However, important questions over their use remain and the field is presently littered with controversy and uncertainty. This review evaluates the progress made and the pitfalls encountered to date, and critically assesses the evidence for the use of stem cells in lung disease.
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January 2008
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Review Article|
December 11 2007
Therapeutic potential of stem cells in lung disease: progress and pitfalls
Michael R. Loebinger;
1Centre of Respiratory Research, Rayne Building, University College London, 5 University Street, London WC1E 6JJ, U.K.
Correspondence: Dr Michael R. Loebinger (email [email protected]).
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Susana Aguilar;
Susana Aguilar
1Centre of Respiratory Research, Rayne Building, University College London, 5 University Street, London WC1E 6JJ, U.K.
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Sam M. Janes
Sam M. Janes
1Centre of Respiratory Research, Rayne Building, University College London, 5 University Street, London WC1E 6JJ, U.K.
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Publisher: Portland Press Ltd
Received:
March 01 2007
Revision Received:
June 05 2007
Accepted:
June 08 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (2): 99–108.
Article history
Received:
March 01 2007
Revision Received:
June 05 2007
Accepted:
June 08 2007
Citation
Michael R. Loebinger, Susana Aguilar, Sam M. Janes; Therapeutic potential of stem cells in lung disease: progress and pitfalls. Clin Sci (Lond) 1 January 2008; 114 (2): 99–108. doi: https://doi.org/10.1042/CS20070073
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