Although several lines of evidence suggest that variation in human inflammation is genetically controlled, the genes which regulate these responses are largely unknown. TLRs (Toll-like receptors) mediate recognition of microbes, regulate activation of the innate immune response and influence the formation of adaptive immunity. Cellular and molecular studies over the past several years have identified a number of common TLR polymorphisms that modify the cellular immune response and production of cytokines in vitro. In addition, human genetic studies suggest that some of these polymorphisms are associated with susceptibility to a spectrum of diseases. In this review, we summarize studies of common TLR polymorphisms and how this work is beginning to illuminate the influence of human variation on inflammation and disease susceptibility.
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March 2008
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Review Article|
February 01 2008
Toll-like receptor polymorphisms and susceptibility to human disease
E. Ann Misch;
E. Ann Misch
1Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, U.S.A.
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Thomas R. Hawn
1Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, U.S.A.
Correspondence: Dr Thomas R. Hawn (email [email protected]).
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Publisher: Portland Press Ltd
Received:
June 26 2007
Revision Received:
August 28 2007
Accepted:
October 01 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (5): 347–360.
Article history
Received:
June 26 2007
Revision Received:
August 28 2007
Accepted:
October 01 2007
Citation
E. Ann Misch, Thomas R. Hawn; Toll-like receptor polymorphisms and susceptibility to human disease. Clin Sci (Lond) 1 March 2008; 114 (5): 347–360. doi: https://doi.org/10.1042/CS20070214
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