There have been only a few reports on the sympathoadrenal and renin–angiotensin systems in children of small gestational age. The purpose of the present study was to investigate plasma levels of ACE (angiotensin-converting enzyme) activity, angiotensin and catecholamines in 8- to 13-year-old children and to determine whether there are correlations between the components of these systems with both birthweight and BP (blood pressure) levels. This clinical study included 66 children (35 boys and 31 girls) in two groups: those born at term with an appropriate birthweight [AGA (appropriate-for-gestational age) group, n=31] and those born at term but with a small birthweight for gestational age [SGA (small-for-gestational age) group, n=35]. Concentrations of angiotensin, catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls (P=0.036). In addition, angiotensin II and ACE activity were higher in SGA boys (P=0.024 and P=0.050 respectively). There was a significant association of the circulating levels of both angiotensin II and ACE activity with BP levels in our study population. Although the underlying mechanisms that link restricted fetal growth with later cardiovascular events are not fully understood, the findings in the present study support the link between low birthweight and overactivity of both sympathoadrenal and renin–angiotensin systems into later childhood.
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March 2008
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Research Article|
February 01 2008
Circulating renin–angiotensin system and catecholamines in childhood: is there a role for birthweight?
Maria C. P. Franco;
*Division of Nephrology, School of Medicine, Federal University of São Paulo, 04023-900 São Paulo, Brazil
Correspondence: Dr Maria C.P. Franco (email [email protected]).
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Dulce E. Casarini;
Dulce E. Casarini
*Division of Nephrology, School of Medicine, Federal University of São Paulo, 04023-900 São Paulo, Brazil
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Marcela S. Carneiro-Ramos;
Marcela S. Carneiro-Ramos
†Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, Brazil
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Ana L. Sawaya;
Ana L. Sawaya
‡Department of Physiology, Federal University of São Paulo, 04023-900 São Paulo, Brazil
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Maria L. M. Barreto-Chaves;
Maria L. M. Barreto-Chaves
†Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, Brazil
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Ricardo Sesso
Ricardo Sesso
*Division of Nephrology, School of Medicine, Federal University of São Paulo, 04023-900 São Paulo, Brazil
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Publisher: Portland Press Ltd
Received:
August 10 2007
Revision Received:
October 04 2007
Accepted:
October 22 2007
Accepted Manuscript online:
October 22 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (5): 375–380.
Article history
Received:
August 10 2007
Revision Received:
October 04 2007
Accepted:
October 22 2007
Accepted Manuscript online:
October 22 2007
Citation
Maria C. P. Franco, Dulce E. Casarini, Marcela S. Carneiro-Ramos, Ana L. Sawaya, Maria L. M. Barreto-Chaves, Ricardo Sesso; Circulating renin–angiotensin system and catecholamines in childhood: is there a role for birthweight?. Clin Sci (Lond) 1 March 2008; 114 (5): 375–380. doi: https://doi.org/10.1042/CS20070284
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