Over the last few years, it has become obvious that obesity and insulin resistance are linked by a variety of proteins secreted by adipocytes. Visfatin/PBEF (pre-B-cell colony-enhancing factor) has recently been identified as a novel adipokine with insulin-mimetic effects. Furthermore, an enzymatic function has been reported that reveals visfatin/PBEF as Nampt (nicotinamide phosphoribosyltransferase; EC 188.8.131.52.). Moreover, reports on the structure and hormonal regulation of visfatin/PBEF/Nampt have given further insights into its potential physiological role. The present review summarizes studies on visfatin/PBEF/Nampt as a novel adipokine.
Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine
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Grit Sommer, Antje Garten, Stefanie Petzold, Annette G. Beck-Sickinger, Matthias Blüher, Michael Stumvoll, Mathias Fasshauer; Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine. Clin Sci (Lond) 1 July 2008; 115 (1): 13–23. doi: https://doi.org/10.1042/CS20070226
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