There is a considerable debate about the potential influence of ‘fetal programming’ on cardiovascular diseases in adulthood. In the present prospective epidemiological cohort study, the relationship between birthweight and arterial elasticity in 472 children between 5 and 8 years of age was assessed. LAEI (large artery elasticity index), SAEI (small artery elasticity index) and BP (blood pressure) were assessed using the HDI/PulseWave™ CR-2000 CardioVascular Profiling System. Blood concentrations of glucose, total cholesterol and its fractions [LDL (low-density lipoprotein)-cholesterol and HDL (high-density lipoprotein)-cholesterol] and triacylglycerols (triglycerides) were determined by automated enzymatic methods. Insulin was assessed by a chemiluminescent method, insulin resistance by HOMA (homoeostasis model assessment) and CRP (C-reactive protein) by immunonephelometry. Two linear regression models were applied to investigate the relationship between the outcomes, LAEI and SAEI, and the following variables: birthweight, gestational age, glucose, LDL-cholesterol, HDL-cholesterol, triacylglycerols, insulin, CRP, HOMA, age, gender, waist circumference, per capita income, SBP (systolic BP) and DBP (diastolic BP). LAEI was positively associated with birthweight (P=0.036), waist circumference (P<0.001) and age (P<0.001), and negatively associated with CRP (P=0.024) and SBP (P<0.001). SAEI was positively associated with birthweight (P=0.04), waist circumference (P=0.001) and age (P<0.001), and negatively associated with DBP (P<0.001). Arterial elasticity was decreased in apparently healthy children who had lower birthweights, indicating an earlier atherogenetic susceptibility to cardiovascular diseases in adolescence and adult life. Possible explanations for the results include changes in angiogenesis during critical phases of intrauterine life caused by periods of fetal growth inhibition and local haemodynamic anomalies as a way of adaptation to abnormal pressure and flow.
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Research Article|
October 15 2008
Relationship between birthweight and arterial elasticity in childhood
Patricia H.C. Rondó;
*Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr Arnaldo 715, São Paulo, SP, CEP-01246-904, Brazil
Correspondence: Dr Patricia H.C. Rondó (email [email protected]).
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Jesuana O. Lemos;
Jesuana O. Lemos
*Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr Arnaldo 715, São Paulo, SP, CEP-01246-904, Brazil
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Joilane A. Pereira;
Joilane A. Pereira
*Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr Arnaldo 715, São Paulo, SP, CEP-01246-904, Brazil
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Julicristie M. Oliveira;
Julicristie M. Oliveira
*Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr Arnaldo 715, São Paulo, SP, CEP-01246-904, Brazil
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Luiz Roberto Innocente
Luiz Roberto Innocente
†School of Physical Education, Parque Municipal Comendador Antonio Carbonari, Jundiaí, SP, CEP-13208-770, Brazil
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Publisher: Portland Press Ltd
Received:
November 27 2007
Revision Received:
April 01 2008
Accepted:
April 07 2008
Accepted Manuscript online:
April 07 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 115 (10): 317–326.
Article history
Received:
November 27 2007
Revision Received:
April 01 2008
Accepted:
April 07 2008
Accepted Manuscript online:
April 07 2008
Citation
Patricia H.C. Rondó, Jesuana O. Lemos, Joilane A. Pereira, Julicristie M. Oliveira, Luiz Roberto Innocente; Relationship between birthweight and arterial elasticity in childhood. Clin Sci (Lond) 1 November 2008; 115 (10): 317–326. doi: https://doi.org/10.1042/CS20070420
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