Pluripotent ES (embryonic stem) cells can be expanded in culture and induced to differentiate into a wide range of cell types. Self-renewal of ES cells involves proliferation with concomitant suppression of differentiation. Some critical and conserved pathways regulating self-renewal in both human and mouse ES cells have been identified, but there is also evidence suggesting significant species differences. Cytoplasmic and receptor tyrosine kinases play important roles in proliferation, survival, self-renewal and differentiation in stem, progenitor and adult cells. The present review focuses on the role of tyrosine kinase signalling for maintenance of the undifferentiated state, proliferation, survival and early differentiation of ES cells.
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July 2008
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Review Article|
June 12 2008
Tyrosine kinase signalling in embryonic stem cells
Cecilia Annerén
1Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, 751 23 Uppsala, Sweden
Correspondence: Dr Cecilia Annerén (e-mail [email protected]).
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Publisher: Portland Press Ltd
Received:
November 01 2007
Revision Received:
January 11 2008
Accepted:
February 08 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 115 (2): 43–55.
Article history
Received:
November 01 2007
Revision Received:
January 11 2008
Accepted:
February 08 2008
Citation
Cecilia Annerén; Tyrosine kinase signalling in embryonic stem cells. Clin Sci (Lond) 1 July 2008; 115 (2): 43–55. doi: https://doi.org/10.1042/CS20070388
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