Acute lung injury results in a severe inflammatory response, which leads to priming and activation of leucocytes, release of reactive oxygen and reactive nitrogen species, destruction of pulmonary endothelium, extravasation of protein-rich fluid into the interstitium and formation of oedema. Recently, H2S (hydrogen sulfide) has been shown to decrease the synthesis of pro-inflammatory cytokines, reduce leucocyte adherence to the endothelium and subsequent diapedesis of these cells from the microvasculature in in vivo studies, and to protect cells in culture from oxidative injury. In the present study, we hypothesized that a parenteral formulation of H2S would reduce the lung injury induced by burn and smoke inhalation in a novel murine model. H2S post-treatment significantly decreased mortality and increased median survival in mice. H2S also inhibited IL (interleukin)-1β levels and significantly increased the concentration of the anti-inflammatory cytokine IL-10 in lung tissue. Additionally, H2S administration attenuated protein oxidation following injury and improved the histological condition of the lung. In conclusion, these results suggest that H2S exerts protective effects in acute lung injury, at least in part through the activation of anti-inflammatory and antioxidant pathways.
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August 2008
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Research Article|
July 02 2008
Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation
Aimalohi Esechie;
Aimalohi Esechie
*Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555, U.S.A.
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Levente Kiss;
Levente Kiss
†Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, U.S.A.
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Gabor Olah;
Gabor Olah
†Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, U.S.A.
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Eszter M. Horváth;
Eszter M. Horváth
†Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, U.S.A.
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Hal Hawkins;
Hal Hawkins
‡Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, U.S.A.
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Csaba Szabo;
Csaba Szabo
†Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, U.S.A.
§Ikaria Inc., Seattle, WA 98102, U.S.A.
∥Department of Anesthesiology and Intensive Care Unit, The University of Texas Medical Branch, Galveston, TX 77555, U.S.A.
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Daniel L. Traber
*Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555, U.S.A.
∥Department of Anesthesiology and Intensive Care Unit, The University of Texas Medical Branch, Galveston, TX 77555, U.S.A.
Correspondence: Professor Daniel L. Traber (email [email protected]).
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Publisher: Portland Press Ltd
Received:
January 18 2008
Revision Received:
February 12 2008
Accepted:
March 03 2008
Accepted Manuscript online:
March 03 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 115 (3): 91–97.
Article history
Received:
January 18 2008
Revision Received:
February 12 2008
Accepted:
March 03 2008
Accepted Manuscript online:
March 03 2008
Citation
Aimalohi Esechie, Levente Kiss, Gabor Olah, Eszter M. Horváth, Hal Hawkins, Csaba Szabo, Daniel L. Traber; Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation. Clin Sci (Lond) 1 August 2008; 115 (3): 91–97. doi: https://doi.org/10.1042/CS20080021
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