Intracellular MAPK (mitogen-activated protein kinase) signalling cascades probably play an important role in the pathogenesis of cardiac and vascular disease. A substantial amount of basic science research has defined many of the details of MAPK pathway organization and activation, but the role of individual signalling proteins in the pathogenesis of various cardiovascular diseases is still being elucidated. In the present review, the role of the MAPKs ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase) and p38 MAPK in cardiac hypertrophy, cardiac remodelling after myocardial infarction, atherosclerosis and vascular restenosis will be examined, with attention paid to genetically modified murine model systems and to the use of pharmacological inhibitors of protein kinases. Despite the complexities of this field of research, attractive targets for pharmacological therapy are emerging.
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October 2008
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Review Article|
September 03 2008
MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets
Anthony J. Muslin
1Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, U.S.A., and the Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, U.S.A.
Correspondence: Dr Anthony J. Muslin (email [email protected]).
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Publisher: Portland Press Ltd
Received:
December 05 2007
Revision Received:
January 29 2008
Accepted:
February 13 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 115 (7): 203–218.
Article history
Received:
December 05 2007
Revision Received:
January 29 2008
Accepted:
February 13 2008
Citation
Anthony J. Muslin; MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets. Clin Sci (Lond) 1 October 2008; 115 (7): 203–218. doi: https://doi.org/10.1042/CS20070430
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