The aim of the present study was to assess circulating levels of VEGF (vascular endothelial growth factor), a biomarker with prognostic significance in cardiovascular disease, and markers of systemic inflammation in patients with stable and exacerbated COPD (chronic obstructive pulmonary disease). Lung function parameters, arterial blood gas analysis and circulating levels of VEGF, IL-6 (interleukin-6), TNF-α (tumour necrosis factor-α), CRP (C-reactive protein), fibrinogen and the peripheral blood neutrophil cell count were assessed in 30 patients on admission to the hospital for acute exacerbation of COPD, in 30 age-, gender- and BMI (body mass index)-matched patients with stable COPD, and 30 matched controls with normal lung function. Patients with acute exacerbated COPD had higher circulating concentrations of VEGF (P<0.001), IL-6 (P<0.05) and CRP (P<0.01) and an increased blood neutrophil cell count (P<0.05) compared with patients with stable COPD and healthy controls. VEGF levels in exacerbated COPD correlated with systemic inflammatory markers, such as CRP (r=0.61, P<0.005), IL-6 (r=0.46; P<0.01) and fibrinogen (r=0.39, P<0.05). In patients with stable COPD, there was a significant relationship between circulating VEGF levels and the percentage of the predicted FEV1 (forced expiratory volume in 1 s) (r=0.47, P<0.01). Recovery from the exacerbation resulted in a significant decrease in both circulating VEGF levels and markers of systemic inflammation. In conclusion, circulating levels of VEGF and markers of systemic inflammation are up-regulated in patients with acute exacerbated COPD and decrease after recovery from the exacerbation.
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October 2008
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Research Article|
September 03 2008
Circulating vascular endothelial growth factor and systemic inflammatory markers in patients with stable and exacerbated chronic obstructive pulmonary disease
Arschang Valipour;
*Department of Respiratory and Critical Care Medicine, Ludwig Boltzmann Institute for Chronic Obstructive Pulmonary Disease, Otto-Wagner-Hospital, Vienna, Austria
Correspondence: Dr Arschang Valipour (email arschang.valipour@wienkav.at).
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Martin Schreder;
Martin Schreder
*Department of Respiratory and Critical Care Medicine, Ludwig Boltzmann Institute for Chronic Obstructive Pulmonary Disease, Otto-Wagner-Hospital, Vienna, Austria
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Michael Wolzt;
Michael Wolzt
†Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria
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Sleman Saliba;
Sleman Saliba
‡Department of Mathematics, Technical University of Kaiserslautern, Kaiserslautern, Germany
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Sonja Kapiotis;
Sonja Kapiotis
§Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Vienna, Austria
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Philipp Eickhoff;
Philipp Eickhoff
*Department of Respiratory and Critical Care Medicine, Ludwig Boltzmann Institute for Chronic Obstructive Pulmonary Disease, Otto-Wagner-Hospital, Vienna, Austria
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Otto Chris Burghuber
Otto Chris Burghuber
*Department of Respiratory and Critical Care Medicine, Ludwig Boltzmann Institute for Chronic Obstructive Pulmonary Disease, Otto-Wagner-Hospital, Vienna, Austria
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Clin Sci (Lond) (2008) 115 (7): 225–232.
Article history
Received:
October 30 2007
Revision Received:
February 04 2008
Accepted:
February 29 2008
Accepted Manuscript online:
February 29 2008
Citation
Arschang Valipour, Martin Schreder, Michael Wolzt, Sleman Saliba, Sonja Kapiotis, Philipp Eickhoff, Otto Chris Burghuber; Circulating vascular endothelial growth factor and systemic inflammatory markers in patients with stable and exacerbated chronic obstructive pulmonary disease. Clin Sci (Lond) 1 October 2008; 115 (7): 225–232. doi: https://doi.org/10.1042/CS20070382
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