Vascular dysfunction in the coronary and peripheral circulations is an early prognostic marker of future cardiovascular events. Measurements of coronary and peripheral vascular function in resistance vessels can be made, but rely on invasive procedures, which make them unsuitable for routine application. An assessment of the direct correlation between vascular responses in skin and coronary vessels has not been made previously. In 27 normal healthy subjects (18–55 years of age), we examined the relationship between peripheral and coronary vascular function. Cutaneous perfusion was measured using the non-invasive technique of laser Doppler imaging during iontophoresis of acetylcholine and sodium nitroprusside, and cutaneous vascular conductance was calculated (laser Doppler perfusion/mean arterial pressure). Coronary flow reserve was measured using transthoracic echocardiography during intravenous adenosine infusion. Mean diastolic velocities were measured at baseline and peak hyperaemic conditions from the Doppler signal recordings. CVR (coronary velocity reserve) was defined as the ratio of hyperaemic to basal mean diastolic velocities. There were significant positive correlations between CVR and cutaneous vascular conductance for acetylcholine (r=0.399, P=0.039) and sodium nitroprusside (r=0.446, P=0.020). These results support the idea that peripheral measurements of skin blood flow are representative of generalized microvascular function including that of the coronary circulation in normal healthy subjects.
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November 2008
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Research Article|
October 01 2008
Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography
Faisel Khan;
*Institute of Cardiovascular Research, University Division of Medicine & Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U.K.
Correspondence: Dr Faisel Khan (email [email protected]).
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Dean Patterson;
Dean Patterson
*Institute of Cardiovascular Research, University Division of Medicine & Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U.K.
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Jill J.F. Belch;
Jill J.F. Belch
*Institute of Cardiovascular Research, University Division of Medicine & Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U.K.
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Kumiko Hirata;
Kumiko Hirata
†Department of Medicine, Columbia University, New York, NY 10032-3784, U.S.A.
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Chim C. Lang
Chim C. Lang
*Institute of Cardiovascular Research, University Division of Medicine & Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U.K.
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Publisher: Portland Press Ltd
Received:
December 05 2007
Revision Received:
February 27 2008
Accepted:
March 13 2008
Accepted Manuscript online:
March 13 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 115 (9): 295–300.
Article history
Received:
December 05 2007
Revision Received:
February 27 2008
Accepted:
March 13 2008
Accepted Manuscript online:
March 13 2008
Citation
Faisel Khan, Dean Patterson, Jill J.F. Belch, Kumiko Hirata, Chim C. Lang; Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography. Clin Sci (Lond) 1 November 2008; 115 (9): 295–300. doi: https://doi.org/10.1042/CS20070431
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