Dysfunction in the cardiovascular system can lead to the progression of a number of disease entities that can involve cancer, diabetes, cardiac ischaemia, neurodegeneration and immune system dysfunction. In order for new therapeutic avenues to overcome some of the limitations of present clinical treatments for these disorders, future investigations must focus upon novel cellular processes that control cellular development, proliferation, metabolism and inflammation. In this respect, members of the mammalian forkhead transcription factors of the O class (FoxOs) have increasingly become recognized as important and exciting targets for disorders of the cardiovascular system. In the present review, we describe the role of these transcription factors in the cardiovascular system during processes that involve angiogenesis, cardiovascular development, hypertension, cellular metabolism, oxidative stress, stem cell proliferation, immune system regulation and cancer. Current knowledge of FoxO protein function combined with future studies should continue to lay the foundation for the successful translation of these transcription factors into novel and robust clinical therapies.
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February 2009
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Review Article|
January 08 2009
FoxO proteins: cunning concepts and considerations for the cardiovascular system
Kenneth Maiese;
*Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
†Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
‡Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
§Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, U.S.A.
∥Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
¶Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
Correspondence: Dr Kenneth Maiese (email [email protected] or [email protected]).
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Zhao Zhong Chong;
Zhao Zhong Chong
*Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
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Yan Chen Shang;
Yan Chen Shang
*Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
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Jinling Hou
Jinling Hou
*Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
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Publisher: Portland Press Ltd
Received:
April 07 2008
Revision Received:
May 19 2008
Accepted:
June 11 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 116 (3): 191–203.
Article history
Received:
April 07 2008
Revision Received:
May 19 2008
Accepted:
June 11 2008
Citation
Kenneth Maiese, Zhao Zhong Chong, Yan Chen Shang, Jinling Hou; FoxO proteins: cunning concepts and considerations for the cardiovascular system. Clin Sci (Lond) 1 February 2009; 116 (3): 191–203. doi: https://doi.org/10.1042/CS20080113
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