Hypertriacylglycerolaemia is an important risk factor for cardiovascular disease. In men, we have shown that the effects of evening exercise on basal VLDL (very-low-density lipoprotein) metabolism are dose-dependent: a single prolonged bout of aerobic exercise [2 h at 60% of V̇O2 peak (peak oxygen consumption)] reduces fasting plasma TAG [triacylglycerol (triglyceride)] concentrations, via enhanced clearance of VLDL-TAG from the circulation, whereas the same exercise performed for 1 h has no effect on VLDL-TAG metabolism and concentration. We hypothesized that women are more sensitive to the TAG-lowering effect of exercise because they reportedly use more intramuscular TAG as an energy source during exercise, and depletion of muscle TAG stores has been linked to reciprocal changes in skeletal muscle LPL (lipoprotein lipase) activity. To test our hypothesis, we measured basal VLDL-TAG and VLDL-apoB-100 (apolipoprotein B-100), and plasma NEFA [non-esterified fatty acid (‘free fatty acid’)] kinetics, by using stable isotope-labelled tracer techniques, on the morning after a single session of evening exercise of moderate duration and intensity (1 h at 60% of V̇O2 peak) in eight sedentary pre-menopausal women (age, 28±3 years; body mass index, 27±2 kg/m2; body fat, 34±3%; values are means±S.E.M.). Compared with an equivalent period of evening rest, exercise had no effect on post-absorptive NEFA concentrations and the rate of appearance in plasma, VLDL-TAG and VLDL-apoB-100 concentrations, hepatic VLDL-TAG and VLDL-apoB-100 secretion and plasma clearance rates (all P>0.05). We conclude that, in women, as in men, a single session of exercise of moderate intensity and duration is not sufficient to bring about the alterations in VLDL metabolism that have been linked to post-exercise hypotriacylglycerolaemia.
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February 2009
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Research Article|
January 15 2009
Basal adipose tissue and hepatic lipid kinetics are not affected by a single exercise bout of moderate duration and intensity in sedentary women
Faidon Magkos;
Faidon Magkos
*Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO 63110, U.S.A.
†Department of Nutrition and Dietetics, Harokopio University, 70 El. Venizelou Ave, Athens 17671, Greece
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Bruce W. Patterson;
Bruce W. Patterson
*Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO 63110, U.S.A.
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B. Selma Mohammed;
B. Selma Mohammed
*Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO 63110, U.S.A.
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Bettina Mittendorfer
*Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO 63110, U.S.A.
Correspondence: Dr Bettina Mittendorfer (email [email protected]).
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Publisher: Portland Press Ltd
Received:
June 13 2008
Revision Received:
August 21 2008
Accepted:
August 27 2008
Accepted Manuscript online:
August 27 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 116 (4): 327–334.
Article history
Received:
June 13 2008
Revision Received:
August 21 2008
Accepted:
August 27 2008
Accepted Manuscript online:
August 27 2008
Citation
Faidon Magkos, Bruce W. Patterson, B. Selma Mohammed, Bettina Mittendorfer; Basal adipose tissue and hepatic lipid kinetics are not affected by a single exercise bout of moderate duration and intensity in sedentary women. Clin Sci (Lond) 1 February 2009; 116 (4): 327–334. doi: https://doi.org/10.1042/CS20080220
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