NAFLD (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis) are of increasing importance, both in connection with insulin resistance and with the development of liver cirrhosis. Histological samples are still the ‘gold standard’ for diagnosis; however, because of the risks of a liver biopsy, non-invasive methods are needed. MAS (magic angle spinning) is a special type of NMR which allows characterization of intact excised tissue without need for additional extraction steps. Because clinical MRI (magnetic resonance imaging) and MRS (magnetic resonance spectroscopy) are based on the same physical principle as NMR, translational research is feasible from excised tissue to non-invasive examinations in humans. In the present issue of Clinical Science, Cobbold and co-workers report a study in three animal strains suffering from different degrees of NAFLD showing that MAS results are able to distinguish controls, fatty infiltration and steatohepatitis in cohorts. In vivo MRS methods in humans are not obtainable at the same spectral resolution; however, know-how from MAS studies may help to identify characteristic changes in crowded regions of the magnetic resonance spectrum.
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March 2009
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Commentary|
February 02 2009
Magic angle spinning magnetic resonance: a novel method opening up translational research into NAFLD?
Chris Boesch
1Department of Clinical Research/AMSM, University of Bern, Pavilion 52 Inselspital, Bern CH-3010, Switzerland
Correspondence: Professor Chris Boesch (email [email protected]).
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Publisher: Portland Press Ltd
Received:
December 02 2008
Accepted:
December 04 2008
Accepted Manuscript online:
December 04 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 116 (5): 401–402.
Article history
Received:
December 02 2008
Accepted:
December 04 2008
Accepted Manuscript online:
December 04 2008
Connected Content
A commentary has been published:
Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue
Citation
Chris Boesch; Magic angle spinning magnetic resonance: a novel method opening up translational research into NAFLD?. Clin Sci (Lond) 1 March 2009; 116 (5): 401–402. doi: https://doi.org/10.1042/CS20080621
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