Angiopoietin-2 is an important mediator of angiogenesis, and we hypothesized that genetic variants of ANGPT2 (the gene encoding angiopoietin-2) would result in abnormal angiogenesis and contribute to stroke susceptibility. To test our hypothesis, we investigated the association of variants in the promoter of ANGPT2 with stroke in a multi-centre case-control study. We found that the C allele of rs3739390 conferred a 1.42-fold risk of lacunar infarction {adjusted OR (odds ratio), 1.42 [95% CI (confidence interval), 1.08–1.87]; P=0.012} and a 2.10-fold higher transcriptional activity than did the corresponding G allele rs3739390G. The haplotype G-G-T conferred a 1.54-fold risk of atherothrombotic stroke and a 1.64-fold risk for haemorrhagic stroke, whereas the haplotype G-C-C conferred approx. a 2.0-fold risk of each subtype of stroke. In conclusion, our results indicate that haplotypes in the promoter of ANGPT2 confer a high risk of stroke in a Chinese population.
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December 2009
Research Article|
September 14 2009
Angiopoietin-2 promoter haplotypes confer an increased risk of stroke in a Chinese Han population
Jingzhou Chen;
Jingzhou Chen
*Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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Hui Yu;
Hui Yu
*Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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Weihua Song;
Weihua Song
*Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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Kai Sun;
Kai Sun
*Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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Yan Song;
Yan Song
*Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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Kejia Lou;
Kejia Lou
*Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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Tao Yang;
Tao Yang
*Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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Yinhui Zhang;
Yinhui Zhang
*Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
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Rutai Hui
*Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
†Hypertension Division, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Correspondence: Dr Rutai Hui (email huirutai@sglab.org).
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Clin Sci (Lond) (2009) 117 (11): 387–395.
Article history
Received:
January 15 2009
Revision Received:
March 18 2009
Accepted:
April 02 2009
Accepted Manuscript online:
April 02 2009
Citation
Jingzhou Chen, Hui Yu, Weihua Song, Kai Sun, Yan Song, Kejia Lou, Tao Yang, Yinhui Zhang, Rutai Hui; Angiopoietin-2 promoter haplotypes confer an increased risk of stroke in a Chinese Han population. Clin Sci (Lond) 1 December 2009; 117 (11): 387–395. doi: https://doi.org/10.1042/CS20090035
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