Increased levels of IMCL (intramyocellular lipid) have been shown to be associated with reduced steady-state glucose infusion rates during a hyperinsulinaemic–euglycaemic clamp (M-value). The aim of the present study was to explore how IMCL levels relate to the insulin-mediated suppression of endogenous glucose production [hepatic SI (insulin sensitivity)] and increase in glucose disposal (peripheral SI). In the present study, 11 healthy young adults (7 male, 4 female; aged 21–31 years) undertook, in random order, an hyperinsulinaemic–euglycaemic clamp combined with stable glucose isotope enrichment to measure peripheral and hepatic SI, a 1H-MRS (proton-magnetic resonance spectroscopy) scan to determine IMCL levels and a DXA (dual-energy X-ray absorptiometry) scan to assess body composition. IMCL levels (range, 3.2–10.7) were associated with whole-body fat mass (r=0.787, P=0.004), fat mass corrected for height (r=0.822, P=0.002) and percentage of central fat mass (r=0.694, P=0.02), but were not related to whole-body FFM (fat-free mass; r=−0.472, P=0.1). IMCL levels correlated closely with the M-value (r=−0.727, P=0.01) and FFM-corrected peripheral SI (r=−0.675, P=0.02), but were not related to hepatic SI adjusted for body weight (r=0.08, P=0.8). The results of the present study suggest that IMCL accumulation may be a sensitive marker for attenuations in peripheral, but not hepatic, SI in normal populations. Given the close relationship of IMCL levels to whole-body and central abdominal fat mass, relative increases in the flux of lipids from adipose tissue to the intramyocellular compartment may be an integral part of the mechanisms underlying reductions in SI.
Skip Nav Destination
Article navigation
August 2009
-
Cover Image
Cover Image
- PDF Icon PDF LinkTable of Contents
Research Article|
July 02 2009
Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects
Burak Salgin;
*University Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, U.K.
Correspondence: Dr Burak Salgin (email [email protected]).
Search for other works by this author on:
Alison J. Sleigh;
Alison J. Sleigh
†Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, U.K.
Search for other works by this author on:
Rachel M. Williams;
Rachel M. Williams
*University Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, U.K.
Search for other works by this author on:
Sarah J. Jackson;
Sarah J. Jackson
‡MRC-Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, U.K.
Search for other works by this author on:
Les J. Bluck;
Les J. Bluck
‡MRC-Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, U.K.
Search for other works by this author on:
Peter R. Murgatroyd;
Peter R. Murgatroyd
§Wellcome Trust Clinical Research Facility, University of Cambridge, Cambridge CB2 0QQ, U.K.
Search for other works by this author on:
Sandy M. Humphreys;
Sandy M. Humphreys
∥Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Headington, Oxford OX3 7LJ, U.K.
Search for other works by this author on:
Sally Harding;
Sally Harding
†Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, U.K.
Search for other works by this author on:
T. Adrian Carpenter;
T. Adrian Carpenter
†Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, U.K.
Search for other works by this author on:
David B. Dunger
David B. Dunger
*University Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
October 30 2008
Revision Received:
December 11 2008
Accepted:
December 18 2008
Accepted Manuscript online:
December 18 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 117 (3): 111–118.
Article history
Received:
October 30 2008
Revision Received:
December 11 2008
Accepted:
December 18 2008
Accepted Manuscript online:
December 18 2008
Citation
Burak Salgin, Alison J. Sleigh, Rachel M. Williams, Sarah J. Jackson, Les J. Bluck, Peter R. Murgatroyd, Sandy M. Humphreys, Sally Harding, T. Adrian Carpenter, David B. Dunger; Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects. Clin Sci (Lond) 1 August 2009; 117 (3): 111–118. doi: https://doi.org/10.1042/CS20080563
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |