The aim of the present study was to assess whether EPC (endothelial progenitor cell) number/function might be an explanatory factor for the observed relationship between Type D personality (a joint tendency towards negative affectivity and social inhibition) and poor cardiovascular prognosis. We also assessed whether the effect of a single exercise bout on EPC number/function was affected by Type D personality. A total of 35 sedentary men with CHF (chronic heart failure; left ventricular ejection fraction ≤45%) underwent CPET (cardiopulmonary exercise testing) and personality assessment with the 14-item Type D scale. CD34+/KDR (kinase insert domain-containing receptor)+ cells were quantified by flow cytometry before and immediately after CPET. Migration of early EPC towards VEGF (vascular endothelial growth factor) and SDF-1α (stromal-cell-derived factor-1α) was investigated. Type D (n=10) and non-Type D (n=25) patients were comparable with regards to demographics, disease severity and Framingham risk factor score. Circulating EPC numbers were reduced by 54% in Type D compared with non-Type D patients (0.084±0.055 and 0.183±0.029% of lymphocytes respectively; P=0.006). Exercise led to a 60% increase in EPC in Type D patients, whereas the EPC number remained unchanged in the non-Type D group (P=0.049). Baseline migratory capacity was related to disease severity, but was not different between Type D and non-Type D patients. Exercise induced a highly significant enhancement of migratory capacity in both groups. In conclusion, reduced EPC numbers might explain the impaired cardiovascular outcome in Type D patients. The larger increase in circulating EPCs observed in these patients suggests that acute exercise elicits a more pronounced stimulus for endothelial repair.
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Research Article|
July 16 2009
Circulating CD34+/KDR+ endothelial progenitor cells are reduced in chronic heart failure patients as a function of Type D personality Available to Purchase
Emeline M. Van Craenenbroeck;
*Department of Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
†Laboratory of Molecular and Cellular Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
‡Center for Cell Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
Correspondence: Dr Emeline Van Craenenbroeck (email [email protected]).
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Johan Denollet;
Johan Denollet
*Department of Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
§Center of Research on Psychology in Somatic diseases (CoRPS), Tilburg University, PO Box 90153, 5000 LE Tilburg, The Netherlands
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Bernard P. Paelinck;
Bernard P. Paelinck
*Department of Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
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Paul Beckers;
Paul Beckers
*Department of Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
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Nadine Possemiers;
Nadine Possemiers
*Department of Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
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Vicky Y. Hoymans;
Vicky Y. Hoymans
†Laboratory of Molecular and Cellular Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
‡Center for Cell Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
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Christiaan J. Vrints;
Christiaan J. Vrints
*Department of Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
†Laboratory of Molecular and Cellular Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
‡Center for Cell Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
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Viviane M. Conraads
Viviane M. Conraads
*Department of Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
†Laboratory of Molecular and Cellular Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
‡Center for Cell Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium
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Publisher: Portland Press Ltd
Received:
October 30 2008
Revision Received:
January 20 2009
Accepted:
January 23 2009
Accepted Manuscript online:
January 23 2009
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 117 (4): 165–172.
Article history
Received:
October 30 2008
Revision Received:
January 20 2009
Accepted:
January 23 2009
Accepted Manuscript online:
January 23 2009
Citation
Emeline M. Van Craenenbroeck, Johan Denollet, Bernard P. Paelinck, Paul Beckers, Nadine Possemiers, Vicky Y. Hoymans, Christiaan J. Vrints, Viviane M. Conraads; Circulating CD34+/KDR+ endothelial progenitor cells are reduced in chronic heart failure patients as a function of Type D personality. Clin Sci (Lond) 1 August 2009; 117 (4): 165–172. doi: https://doi.org/10.1042/CS20080564
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