High adiponectin concentrations have emerged as an independent risk factor of outcome in patients with CHF (chronic heart failure); however, modification of adiponectin in CHF patients has not been assessed to date. The aim of the present study was to investigate the effect of exercise training on adiponectin levels in CHF patients. A total of 80 patients with CHF due to systolic dysfunction were included. The effect of 4 months exercise training was studied in 46 patients, whereas the remaining 34 untrained CHF patients served as a sedentary control group. Circulating adiponectin concentrations, exercise capacity, anthropometric data and NT-proBNP (N-terminal pro-brain natriuretic peptide) levels were assessed. Adiponectin levels were significantly higher in CHF patients compared with healthy subjects [9.3 (7.1–16.1) and 4.9 (3.9–8.6) mg/l respectively; P=0.015]. Stratification of CHF patients according to tertiles of NT-proBNP revealed an increase in adiponectin with disease severity (P<0.0001). Exercise training reduced circulating adiponectin levels in CHF patients [10.7 (7.2–17.6) mg/l before training to 9.4 (5.9–14.8) mg/l after training; P=0.013], whereas no changes were observed in the sedentary CHF group [9.0 (7.0–13.5) mg/l before training and 10.1 (6.0–15.7) mg/l after a similar time interval]. A significant time×group interaction (P=0.008) was observed for the mean change in adiponectin between the trained and untrained CHF patients. Adiponectin concentrations were positively associated with NT-proBNP and HDL (high-density lipoprotein)-cholesterol and negatively correlated with BMI (body mass index), triacylglycerols and exercise capacity. In conclusion, circulating adiponectin concentrations are higher in CHF patients compared with healthy subjects and increase with disease severity. Exercise training for 4 months lowers circulating adiponectin levels.
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Research Article|
November 16 2009
Exercise training reduces circulating adiponectin levels in patients with chronic heart failure
An M. Van Berendoncks;
*Department of Cardiology, Antwerp University Hospital, 2650 Edegem, Belgium
†Laboratory for Cellular and Molecular Cardiology, Center for Cell Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, 2650 Edegem, Belgium
‡University of Antwerp, 2610 Antwerp, Belgium
Correspondence: Dr An Van Berendoncks (e-mail [email protected]).
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Paul Beckers;
Paul Beckers
*Department of Cardiology, Antwerp University Hospital, 2650 Edegem, Belgium
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Vicky Y. Hoymans;
Vicky Y. Hoymans
*Department of Cardiology, Antwerp University Hospital, 2650 Edegem, Belgium
†Laboratory for Cellular and Molecular Cardiology, Center for Cell Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, 2650 Edegem, Belgium
‡University of Antwerp, 2610 Antwerp, Belgium
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Nadine Possemiers;
Nadine Possemiers
*Department of Cardiology, Antwerp University Hospital, 2650 Edegem, Belgium
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Floris L. Wuyts;
Floris L. Wuyts
§Department of Biomedical Statistics, Antwerp University Hospital, 2650 Edegem, Belgium
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Christiaan J. Vrints;
Christiaan J. Vrints
*Department of Cardiology, Antwerp University Hospital, 2650 Edegem, Belgium
†Laboratory for Cellular and Molecular Cardiology, Center for Cell Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, 2650 Edegem, Belgium
‡University of Antwerp, 2610 Antwerp, Belgium
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Viviane M. Conraads
Viviane M. Conraads
*Department of Cardiology, Antwerp University Hospital, 2650 Edegem, Belgium
†Laboratory for Cellular and Molecular Cardiology, Center for Cell Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, 2650 Edegem, Belgium
‡University of Antwerp, 2610 Antwerp, Belgium
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Publisher: Portland Press Ltd
Received:
April 08 2009
Revision Received:
July 31 2009
Accepted:
August 06 2009
Accepted Manuscript online:
August 06 2009
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2010 Biochemical Society
2010
Clin Sci (Lond) (2010) 118 (4): 281–289.
Article history
Received:
April 08 2009
Revision Received:
July 31 2009
Accepted:
August 06 2009
Accepted Manuscript online:
August 06 2009
Citation
An M. Van Berendoncks, Paul Beckers, Vicky Y. Hoymans, Nadine Possemiers, Floris L. Wuyts, Christiaan J. Vrints, Viviane M. Conraads; Exercise training reduces circulating adiponectin levels in patients with chronic heart failure. Clin Sci (Lond) 1 February 2010; 118 (4): 281–289. doi: https://doi.org/10.1042/CS20090213
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