Evidence exists for the potential protective effects of circulating ovarian hormones in stroke, and oestrogen reduces brain damage in animal ischaemia models. However, a recent clinical trial indicated that HRT (hormone-replacement therapy) increased the incidence of stroke in post-menopausal women, and detrimental effects of oestrogen on stroke outcome have been identified in a meta-analysis of HRT trials and in pre-clinical research studies. Therefore oestrogen is not an agent that can be promoted as a potential stroke therapy. Many published reviews have reported the neuroprotective effects of oestrogen in stroke, but have failed to include information on the detrimental effects. This issue is addressed in the present review, along with potential mechanisms of action, and the translational capacity of pre-clinical research.
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Review Article| December 15 2009
Complexities of oestrogen in stroke
Hilary V.O. Carswell;
*Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, Scotland, U.K.
Correspondence: Dr Hilary V.O. Carswell (email firstname.lastname@example.org).
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I. Mhairi Macrae;
Publisher: Portland Press Ltd
Received: May 01 2009
Revision Received: October 06 2009
Accepted: October 21 2009
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2010 Biochemical Society
Hilary V.O. Carswell, I. Mhairi Macrae, Tracy D. Farr; Complexities of oestrogen in stroke. Clin Sci (Lond) 1 March 2010; 118 (6): 375–389. doi: https://doi.org/10.1042/CS20090018
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