NAFLD (non-alcoholic fatty liver disease) represents a spectrum of fatty liver diseases associated with an increased risk of Type 2 diabetes and cardiovascular disease. The spectrum of fatty liver diseases comprises simple steatosis, steatosis with inflammation [i.e. NASH (non-alcoholic steatohepatitis)], fatty liver disease with inflammation and fibrosis (severe NASH) and cirrhosis. The molecular mechanisms contributing to NASH are the subject of considerable investigation, as a better understanding of the pathogenesis of NASH will lead to novel therapies for a condition that hitherto remains difficult to treat. In the present issue of Clinical Science, Piguet and co-workers have investigated the effects of hypoxia in the PTEN (phosphatase and tensin homologue deleted on chromosome 10)-deficient mouse, a mouse model that develops NAFLD. The authors show that a short period (7 days) of exposure to hypoxia aggravates the NAFLD phenotype, causing changes in the liver that are in keeping with NASH with increased lipogenesis and inflammation.
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Commentary| December 14 2009
Hypoxia and non-alcoholic fatty liver disease
Christopher D. Byrne
1Department of Endocrinology and Metabolism, The Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, U.K.
Correspondence: Professor Christopher D. Byrne (email email@example.com).
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Christopher D. Byrne; Hypoxia and non-alcoholic fatty liver disease. Clin Sci (Lond) 1 March 2010; 118 (6): 397–400. doi: https://doi.org/10.1042/CS20090565
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