TRP (transient receptor potential) channels play important roles in the regulation of normal and pathological cellular function. In the vasculature, TRP channels are present both in ECs (endothelial cells) and vascular SMCs (smooth muscle cells) and contribute to vasomotor control mechanisms in most vascular beds. Vascular TRP channels are activated by various stimuli, such as mechanical perturbation, receptor activation and dietary molecules. Some of the specific roles of these channels in normal and impaired vascular function have emerged in recent years and include participation in vascular signalling processes, such as neurotransmission, hormonal signalling, NO production, myogenic tone and autoregulation of blood flow, thermoregulation, responses to oxidative stress and cellular proliferative activity. Current research is aimed at understanding the interactions of TRP channels with other vascular proteins and signalling mechanisms. These studies should reveal new targets for pharmacological therapy of vascular diseases, such as hypertension, ischaemia and vasospasm, and vascular proliferative states.
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Review Article|
April 07 2010
Transient receptor potential channels and vascular function
Scott Earley;
Scott Earley
*Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, U.S.A.
†Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405, U.S.A.
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Joseph E. Brayden
†Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405, U.S.A.
Correspondence: Dr Joseph E. Brayden (email [email protected]).
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Publisher: Portland Press Ltd
Received:
December 07 2009
Revision Received:
February 05 2010
Accepted:
February 09 2010
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2010 Biochemical Society
2010
Clin Sci (Lond) (2010) 119 (1): 19–36.
Article history
Received:
December 07 2009
Revision Received:
February 05 2010
Accepted:
February 09 2010
Citation
Scott Earley, Joseph E. Brayden; Transient receptor potential channels and vascular function. Clin Sci (Lond) 1 July 2010; 119 (1): 19–36. doi: https://doi.org/10.1042/CS20090641
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