Exercise is part of a healthy lifestyle and frequently is an important component in combating chronic diseases, such as obesity and diabetes. Understanding the molecular events initiated by regular exercise is best studied in laboratory animals, with mice and rats being favoured for a number of reasons. However, the wide variety of rodent strains available for biomedical research often makes it challenging to select an animal strain suitable for studying specific disease outcomes. In the present review we focus on exercise as a management strategy for obesity and diabetes and we discuss: (i) exercise paradigms in humans shown to ameliorate signs and symptoms of obesity and diabetes; (ii) different rodent strains in terms of their advantages, disadvantages and limitations when using specific forms of exercise; (iii) the strengths and weaknesses of commonly used laboratory methods for rodent exercise; and (iv) the unintended consequences of exercise that are often manifested by increased hormonal and oxidative stress responses.
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Review Article|
April 20 2010
Selecting exercise regimens and strains to modify obesity and diabetes in rodents: an overview
Sanjoy Ghosh
;
Sanjoy Ghosh
*Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
†Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
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Saeid Golbidi
;
Saeid Golbidi
†Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
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Isa Werner
;
Isa Werner
*Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
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Bruce C. Verchere
;
Bruce C. Verchere
*Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
‡Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
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Ismail Laher
†Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
Correspondence: Dr Ismail Laher (email ilaher@interchange.ubc.ca).
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Clin Sci (Lond) (2010) 119 (2): 57–74.
Article history
Received:
July 21 2009
Revision Received:
February 02 2010
Accepted:
February 09 2010
Citation
Sanjoy Ghosh, Saeid Golbidi, Isa Werner, Bruce C. Verchere, Ismail Laher; Selecting exercise regimens and strains to modify obesity and diabetes in rodents: an overview. Clin Sci (Lond) 1 July 2010; 119 (2): 57–74. doi: https://doi.org/10.1042/CS20090389
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