Although increases in cTnI (cardiac troponin I) and cTnT (cardiac troponin T) always indicate myocardial damage, the test is not able to identify the mechanisms responsible for this damage, which may not be due to ischaemia, but rather to other clinical conditions. In the present issue of Clinical Science, Filusch and co-workers have assessed cTnT using a high-sensitive assay in patients with pulmonary arterial hypertension. Their study suggests that, even in patients with extracardiac diseases, high-sensitive troponin assays could lead to better risk stratification of patients in whom conventional cTnT assays show values within the ‘normal’ range. These findings support the hypothesis that increased levels of cTnI and cTnT are an index of cardiac tissue damage, even in patients with extracardiac diseases, thus enabling appropriate diagnosis and, when necessary and available, specific treatment.
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Commentary|
June 02 2010
Will high-sensitive troponin immunoassays lead to more clarity or confusion in clinical practice?
Aldo Clerico;
1Laboratory of Cardiovascular Endocrinology and Cell Biology, Scuola Superiore Sant'Anna and Fondazione CNR, Regione Toscana Gabriele Monasterio, 56126 Pisa, Italy
Correspondence: Professor Aldo Clerico (email [email protected]).
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Alberto Giannoni
Alberto Giannoni
1Laboratory of Cardiovascular Endocrinology and Cell Biology, Scuola Superiore Sant'Anna and Fondazione CNR, Regione Toscana Gabriele Monasterio, 56126 Pisa, Italy
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Publisher: Portland Press Ltd
Received:
April 29 2010
Accepted:
May 04 2010
Accepted Manuscript online:
May 04 2010
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2010 Biochemical Society
2010
Clin Sci (Lond) (2010) 119 (5): 203–205.
Article history
Received:
April 29 2010
Accepted:
May 04 2010
Accepted Manuscript online:
May 04 2010
Citation
Aldo Clerico, Alberto Giannoni; Will high-sensitive troponin immunoassays lead to more clarity or confusion in clinical practice?. Clin Sci (Lond) 1 August 2010; 119 (5): 203–205. doi: https://doi.org/10.1042/CS20100234
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