The 21-amino-acid peptide ET-1 (endothelin-1) regulates a diverse array of physiological processes, including vasoconstriction, angiogenesis, nociception and cell proliferation. Most of the effects of ET-1 are associated with an increase in intracellular calcium concentration. The calcium influx and mobilization pathways activated by ET-1, however, vary immensely. The present review begins with the basics of calcium signalling and investigates the different ways intracellular calcium concentration can increase in response to a stimulus. The focus then shifts to ET-1, and discusses how ET receptors mobilize calcium. We also examine how disease alters calcium-dependent responses to ET-1 by discussing changes to ET-1-mediated calcium signalling in hypertension, as there is significant interest in the role of ET-1 in this important disease. A list of unanswered questions regarding ET-mediated calcium signals are also presented, as well as perspectives for future research of calcium mobilization by ET-1.
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Review Article|
July 23 2010
The interdependence of endothelin-1 and calcium: a review
Nathan R. Tykocki;
1Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, U.S.A.
Correspondence: Mr Nathan R. Tykocki (email tykockin@msu.edu).
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Stephanie W. Watts
Stephanie W. Watts
1Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, U.S.A.
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Clin Sci (Lond) (2010) 119 (9): 361–372.
Article history
Received:
March 03 2010
Revision Received:
June 10 2010
Accepted:
June 23 2010
Citation
Nathan R. Tykocki, Stephanie W. Watts; The interdependence of endothelin-1 and calcium: a review. Clin Sci (Lond) 1 October 2010; 119 (9): 361–372. doi: https://doi.org/10.1042/CS20100145
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