Cardiovascular disease remains the leading cause of death worldwide. Despite progress in management, there remain a significant number of patients who are not eligible for current treatment options. Traditionally, HO-1 (haem oxygenase-1), one of two isoenzymes that initiate haem catabolism, was thought to only play a metabolic role. However, HO-1 is now recognized to have additional protective activities in states of heightened noxious stimuli or stress such as acute coronary syndromes. The present review article provides an overview of the mode of action of HO-1 in vascular protection, with particular emphasis on its atheroprotective, anti-inflammatory and antioxidative properties, as well as its role in vascular repair. Furthermore, we present evidence for the protective effects of HO-1 in CVD (cardiovascular disease) in both animal and human studies. Given its potential in vascular protection and repair, strategies aimed at inducing HO-1 emerge as a novel and alternative therapeutic target in the management of CVD.
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Review Article|
March 01 2011
Haem oxygenase-1 and cardiovascular disease: mechanisms and therapeutic potential
Kim H. Chan;
Kim H. Chan
*Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
†The Heart Research Institute, Newtown, NSW 2042, Australia
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Martin K. C. Ng;
Martin K. C. Ng
*Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
†The Heart Research Institute, Newtown, NSW 2042, Australia
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Roland Stocker
‡School of Medical Sciences (Pathology) and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia
Correspondence: Professor Roland Stocker (email [email protected]).
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Publisher: Portland Press Ltd
Received:
October 15 2010
Revision Received:
November 23 2010
Accepted:
December 08 2010
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2011 Biochemical Society
2011
Clin Sci (Lond) (2011) 120 (12): 493–504.
Article history
Received:
October 15 2010
Revision Received:
November 23 2010
Accepted:
December 08 2010
Citation
Kim H. Chan, Martin K. C. Ng, Roland Stocker; Haem oxygenase-1 and cardiovascular disease: mechanisms and therapeutic potential. Clin Sci (Lond) 1 June 2011; 120 (12): 493–504. doi: https://doi.org/10.1042/CS20100508
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