H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a ubiquitously present and physiologically relevant signalling molecule. Knowledge of the production and metabolism of H2S has spurred interest in delineating its functions both in physiology and pathophysiology of disease. Although its role in blood pressure regulation and interaction with NO is controversial, H2S, through its anti-apoptotic, anti-inflammatory and antioxidant effects, has demonstrated significant cardioprotection. As a result, a number of sulfide-donor drugs, including garlic-derived polysulfides, are currently being designed and investigated for the treatment of cardiovascular conditions, specifically myocardial ischaemic disease. However, huge gaps remain in our knowledge about this gasotransmitter. Only by additional studies will we understand more about the role of this intriguing molecule in the treatment of cardiovascular disease.
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Review Article| December 03 2010
Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential
David J. Lefer
1Department of Surgery, Division of Cardiothoracic Surgery, The Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, U.S.A.
Correspondence: Professor David J. Lefer (email email@example.com).
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Publisher: Portland Press Ltd
Received: September 15 2010
Revision Received: October 27 2010
Accepted: October 29 2010
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2011 Biochemical Society
Madhav Lavu, Shashi Bhushan, David J. Lefer; Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential. Clin Sci (Lond) 1 March 2011; 120 (6): 219–229. doi: https://doi.org/10.1042/CS20100462
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