The diagnosis of cancer has undergone major changes in the last 40 years. Once based purely on morphology, diagnosis has come to incorporate immunological, cytogenetic and molecular methods. Many cancers, especially leukaemias, are now defined by molecular markers. Gene expression profiling based on mRNA has led to further refinement of the classification and diagnosis of cancer. More recently, miRNAs (microRNAs), among other small non-coding RNA molecules, have been discovered and found to be major players in cell biology. miRNAs, having both oncogenic and tumour-suppressive functions, are dysregulated in many types of cancer. miRNAs also interfere with metastasis, apoptosis and invasiveness of cancer cells. In the present review, we discuss recent advances in miRNA profiling in human cancer. We discuss both frequent and rare tumour types and give an outlook on future developments.
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Review Article| April 20 2011
MicroRNA profiling in cancer
*Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A.
†Department of Medicine and Feist–Weiller Cancer Center, Louisiana State University Shreveport, Shreveport, LA 71130, U.S.A.
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Publisher: Portland Press Ltd
Received: January 06 2011
Revision Received: March 03 2011
Accepted: March 11 2011
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2011 Biochemical Society
Reinhold Munker, George A. Calin; MicroRNA profiling in cancer. Clin Sci (Lond) 1 August 2011; 121 (4): 141–158. doi: https://doi.org/10.1042/CS20110005
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