Sirtuins are NAD+-dependent protein deacetylases that are broadly conserved from bacteria to humans. Because sirtuins extend the lifespan of yeast, worms and flies, much attention has been paid to their mammalian homologues. Recent studies have revealed diverse physiological functions of sirtuins that are essentially similar to those of their yeast homologue, Sir2 (silent information regulator 2). Sirtuins are implicated in the pathology of many diseases, for which sirtuin activators such as resveratrol have great promise as potential treatments. In the present review, we describe the functions of sirtuins in cell survival, inflammation, energy metabolism, cancer and differentiation, and their impact on diseases. We also discuss the organ-specific functions of sirtuins, focusing on the brain and blood vessels.
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Review Article|
May 20 2011
Cellular and molecular effects of sirtuins in health and disease
Yoshiyuki Horio;
1Department of Pharmacology, Sapporo Medical University, Sapporo 060-8556, Japan
Correspondence: Professor Yoshiyuki Horio (email [email protected]).
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Takashi Hayashi;
Takashi Hayashi
1Department of Pharmacology, Sapporo Medical University, Sapporo 060-8556, Japan
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Atsushi Kuno;
Atsushi Kuno
1Department of Pharmacology, Sapporo Medical University, Sapporo 060-8556, Japan
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Risa Kunimoto
Risa Kunimoto
1Department of Pharmacology, Sapporo Medical University, Sapporo 060-8556, Japan
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Publisher: Portland Press Ltd
Received:
December 03 2010
Revision Received:
March 10 2011
Accepted:
March 11 2011
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2011 Biochemical Society
2011
Clin Sci (Lond) (2011) 121 (5): 191–203.
Article history
Received:
December 03 2010
Revision Received:
March 10 2011
Accepted:
March 11 2011
Citation
Yoshiyuki Horio, Takashi Hayashi, Atsushi Kuno, Risa Kunimoto; Cellular and molecular effects of sirtuins in health and disease. Clin Sci (Lond) 1 September 2011; 121 (5): 191–203. doi: https://doi.org/10.1042/CS20100587
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