The TGF-β (transforming growth factor-β) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal transduction has allowed a better understanding of the disease pathogenicity as well as the identification of several molecular targets with great potential in therapeutic interventions.
TGF-β/TGF-β receptor system and its role in physiological and pathological conditions
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Juan F. Santibañez, Miguel Quintanilla, Carmelo Bernabeu; TGF-β/TGF-β receptor system and its role in physiological and pathological conditions. Clin Sci (Lond) 1 September 2011; 121 (6): 233–251. doi: https://doi.org/10.1042/CS20110086
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