Magnesium (Mg2+) balance is tightly regulated by the concerted actions of the intestine, bone and kidneys. This balance can be disturbed by a broad variety of drugs. Diuretics, modulators of the EGFR (epidermal growth factor receptor), proton pump inhibitors, antimicrobials, calcineurin inhibitors and cytostatics may all cause hypomagnesaemia, potentially leading to tetany, seizures and cardiac arrhythmias. Conversely, high doses of Mg2+ salts, frequently administered as an antacid or a laxative, may lead to hypermagnesaemia causing various cardiovascular and neuromuscular abnormalities. A better understanding of the molecular mechanisms underlying the adverse effects of these medications on Mg2+ balance will indicate ways of prevention and treatment of these adverse effects and could potentially provide more insight into Mg2+ homoeostasis.
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Review Article|
March 12 2012
Drug-induced alterations in Mg2+ homoeostasis
Anke L. Lameris
;
Anke L. Lameris
1Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
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Leo A. Monnens
;
Leo A. Monnens
1Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
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René J. Bindels
;
René J. Bindels
1Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
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Joost G. J. Hoenderop
1Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Correspondence: Professor Joost G.J. Hoenderop (email j.hoenderop@fysiol.umcn.nl).
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Clin Sci (Lond) (2012) 123 (1): 1–14.
Article history
Received:
January 24 2012
Accepted:
January 31 2012
Citation
Anke L. Lameris, Leo A. Monnens, René J. Bindels, Joost G. J. Hoenderop; Drug-induced alterations in Mg2+ homoeostasis. Clin Sci (Lond) 1 July 2012; 123 (1): 1–14. doi: https://doi.org/10.1042/CS20120045
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