The aim of the present study was to evaluate the effects of ST (rosuvastatin) and GZ (rosiglitazone) on IR (insulin resistance) and on liver as well as adipose tissue in mice fed on an HF (high-fat) diet. Our data show that treatment with ST resulted in a marked improvement in insulin sensitivity characterized by enhanced glucose clearance during the insulin tolerance test and a 70% decrease in the HOMA-IR (homoeostasis model assessment of insulin resistance) index level (P=0.0008). The ST-treated mice exhibited lower gains in BM (body mass; −8%; P<0.01) and visceral fat pad thickness (−60%; P<0.01) compared with the untreated HF group. In comparison with HF-diet-fed mice, HF+ST-treated mice showed a significant reduction in hepatomegaly and liver steatosis (−6%, P<0.05; and −21%, P<0.01 respectively). In HF+ST-treated mice, the hepatic TAG (triacylglycerol) levels were reduced by 58% compared with the HF group (P<0.01). In addition, the expression of SREBP-1c (sterol-regulatory-element-binding protein-1c) was decreased by 50% in the livers of HF+ST-treated mice (P<0.01) relative to the HF-diet-fed mice. The levels of resistin were lower in the HF+ST-treated group compared with the HF group (44% less, P< 0.01). In conclusion, we demonstrated that ST treatment improved insulin sensitivity and decreased liver steatosis in mice fed on an HF diet. Furthermore, ST reduced BM gains, improved the circulating levels of plasma cholesterol and TAG, and reduced hepatic TAG, which was concomitant with lower resistin levels.
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Research Article|
April 30 2012
Beneficial effects of rosuvastatin on insulin resistance, adiposity, inflammatory markers and non-alcoholic fatty liver disease in mice fed on a high-fat diet
Julio Cesar Fraulob;
Julio Cesar Fraulob
1Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, State University of Rio de Janeiro, Brazil
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Vanessa Souza-Mello;
Vanessa Souza-Mello
1Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, State University of Rio de Janeiro, Brazil
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Marcia Barbosa Aguila;
Marcia Barbosa Aguila
1Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, State University of Rio de Janeiro, Brazil
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Carlos Alberto Mandarim-de-Lacerda
1Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, State University of Rio de Janeiro, Brazil
Correspondence: Professor Carlos Alberto Mandarim-de-Lacerda (email [email protected]).
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Publisher: Portland Press Ltd
Received:
July 21 2011
Revision Received:
March 14 2012
Accepted:
March 15 2012
Accepted Manuscript online:
March 15 2012
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2012 Biochemical Society
2012
Clin Sci (Lond) (2012) 123 (4): 259–270.
Article history
Received:
July 21 2011
Revision Received:
March 14 2012
Accepted:
March 15 2012
Accepted Manuscript online:
March 15 2012
Citation
Julio Cesar Fraulob, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda; Beneficial effects of rosuvastatin on insulin resistance, adiposity, inflammatory markers and non-alcoholic fatty liver disease in mice fed on a high-fat diet. Clin Sci (Lond) 1 August 2012; 123 (4): 259–270. doi: https://doi.org/10.1042/CS20110373
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