ACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin II receptor blockers) are already widely used for the treatment and prevention of cardiovascular disease and their potential role in other disease states has become increasingly recognized. COPD (chronic obstructive pulmonary disease) is characterized by pathological inflammatory processes involving the lung parenchyma, airways and vascular bed. The aim of the present review is to outline the role of the RAS (renin–angiotensin system) in the pathogenesis of COPD, including reference to results from fibrotic lung conditions and pulmonary hypertension. The review will, in particular, address the emerging evidence that ACE inhibition could have a beneficial effect on skeletal muscle function and cardiovascular co-morbidity in COPD patients. The evidence to support the effect of RAS blockade as a novel therapeutic approach in COPD will be discussed.
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Review Article|
June 27 2012
Renin–angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease
Dinesh Shrikrishna;
*NIHR Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, U.K.
†Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London, U.K.
Correspondence: Dr Dinesh Shrikrishna (email [email protected]).
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Ronan Astin;
Ronan Astin
‡Institute for Human Health and Performance, University College London, London, U.K.
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Paul R. Kemp;
Paul R. Kemp
†Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London, U.K.
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Nicholas S. Hopkinson
Nicholas S. Hopkinson
*NIHR Respiratory Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, U.K.
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Publisher: Portland Press Ltd
Received:
February 14 2012
Revision Received:
March 23 2012
Accepted:
April 25 2012
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2012 Biochemical Society
2012
Clin Sci (Lond) (2012) 123 (8): 487–498.
Article history
Received:
February 14 2012
Revision Received:
March 23 2012
Accepted:
April 25 2012
Citation
Dinesh Shrikrishna, Ronan Astin, Paul R. Kemp, Nicholas S. Hopkinson; Renin–angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease. Clin Sci (Lond) 1 October 2012; 123 (8): 487–498. doi: https://doi.org/10.1042/CS20120081
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