HDACs (histone deacetylases) are a group of enzymes that deacetylate histones as well as non-histone proteins. They are known as modulators of gene transcription and are associated with proliferation and differentiation of a variety of cell types and the pathogenesis of some diseases. Recently, HDACs have come to be considered crucial targets in various diseases, including cancer, interstitial fibrosis, autoimmune and inflammatory diseases, and metabolic disorders. Pharmacological inhibitors of HDACs have been used or tested to treat those diseases. In the present review, we will examine the application of HDAC inhibitors in a variety of diseases with the focus on their effects of anti-cancer, fibrosis, anti-inflammatory, immunomodulatory activity and regulating metabolic disorders.
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Review Article|
February 15 2013
Histone deacetylases as targets for treatment of multiple diseases
Jinhua Tang;
Jinhua Tang
*Department of Nephrology, Tongji University School of Medicine, Shanghai East Hospital, Shanghai, China
†Department of Medicine, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, U.S.A.
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Haidong Yan;
*Department of Nephrology, Tongji University School of Medicine, Shanghai East Hospital, Shanghai, China
Correspondence: Dr Shougang Zhuang (email szhuang@lifespan.org) or Dr Haidong Yan (email yhdcmu@sina.com).
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Shougang Zhuang
*Department of Nephrology, Tongji University School of Medicine, Shanghai East Hospital, Shanghai, China
†Department of Medicine, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, U.S.A.
Correspondence: Dr Shougang Zhuang (email szhuang@lifespan.org) or Dr Haidong Yan (email yhdcmu@sina.com).
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Clin Sci (Lond) (2013) 124 (11): 651–662.
Article history
Received:
September 17 2012
Revision Received:
December 03 2012
Accepted:
December 07 2012
Citation
Jinhua Tang, Haidong Yan, Shougang Zhuang; Histone deacetylases as targets for treatment of multiple diseases. Clin Sci (Lond) 1 June 2013; 124 (11): 651–662. doi: https://doi.org/10.1042/CS20120504
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