Corin is a cardiac protease that regulates BP (blood pressure) by activating natriuretic peptides. Recent animal studies identified corin expression in the kidney where it may regulate renal function. In the present study, we tested the hypothesis that corin may be present in human urine and that urinary corin levels may be altered in patients with kidney disease. We obtained urine and kidney tissue samples from normal individuals and CKD (chronic kidney disease) patients. Using ELISA, we detected corin protein in human urine. In normal individuals, urinary corin levels did not correlate with that of plasma, indicating that urinary corin is probably of kidney origin. Compared with normal controls, CKD patients had markedly reduced urinary corin levels and this reduction correlated with disease severity. By immunostaining, human corin protein was identified on the epithelial cell surface in renal tubules. The renal corin mRNA and protein levels were significantly lower in CKD patients than non-CKD controls. The results indicate that renal tubular corin may be shed into urine and that urinary and renal corin levels were reduced in CKD patients. These data suggest that reduced corin levels in the kidney may reflect the underlying pathology in CKD.
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Research Article|
February 26 2013
Reduced urinary corin levels in patients with chronic kidney disease
Chaodong Fang;
Chaodong Fang
1
*The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, People's Republic of China
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Lei Shen;
Lei Shen
1
†Department of Nephrology, the First Affiliated Hospital of Soochow University, Suzhou 215006, People's Republic of China
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Liang Dong;
Liang Dong
*The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, People's Republic of China
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Meng Liu;
Meng Liu
*The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, People's Republic of China
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Sensen Shi;
Sensen Shi
*The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, People's Republic of China
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Ningzheng Dong;
*The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, People's Republic of China
‡Thrombosis and Hemostasis Key Laboratory of the Ministry of Health, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou 215006, People's Republic of China
Correspondence: Dr Qingyu Wu (email [email protected]) or Dr Ningzheng Dong (email [email protected].).
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Qingyu Wu
*The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, People's Republic of China
§Molecular Cardiology, Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH 44195, U.S.A.
Correspondence: Dr Qingyu Wu (email [email protected]) or Dr Ningzheng Dong (email [email protected].).
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Publisher: Portland Press Ltd
Received:
September 21 2012
Revision Received:
January 16 2013
Accepted:
January 18 2013
Accepted Manuscript online:
January 18 2013
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2013 Biochemical Society
2013
Clin Sci (Lond) (2013) 124 (12): 709–717.
Article history
Received:
September 21 2012
Revision Received:
January 16 2013
Accepted:
January 18 2013
Accepted Manuscript online:
January 18 2013
Citation
Chaodong Fang, Lei Shen, Liang Dong, Meng Liu, Sensen Shi, Ningzheng Dong, Qingyu Wu; Reduced urinary corin levels in patients with chronic kidney disease. Clin Sci (Lond) 1 June 2013; 124 (12): 709–717. doi: https://doi.org/10.1042/CS20120517
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