A-FABP (adipocyte fatty acid-binding protein), one of the most abundant proteins in adipocytes, plays a key role in obesity-related insulin resistance, inflammation and atherosclerosis in animals. In the present study, we sought to investigate the association of A-FABP with HF (heart failure) in Chinese subjects. Serum A-FABP levels were measured in 252 HF patients and 261 age-, gender- and BMI (body mass index)-matched non-HF subjects. Echocardiography was performed on each patient. The severity of HF was determined by the NYHA (New York Heart Association) classification system. After adjustments for age, gender and BMI, serum A-FABP concentrations in patients with HF were significantly higher than in non-HF patients [11.17 (6.63–19.93) ng/ml compared with 5.67 (3.20–8.87) ng/ml; P<0.001] and significantly progressed with the NYHA class (P<0.001). In addition, NT-proBNP (N-terminal pro-brain natriuretic peptide) was independently and positively correlated with A-FABP (standardized β=0.340, P<0.001) after adjusting for confounding factors. Each echocardiographic parameter, especially LVEF (left ventricular ejection fraction), was independently associated with A-FABP (all P<0.05). Multivariate logistic regression analysis demonstrated that A-FABP concentration was an independent risk factor for HF [odds ratio, 6.93 (95% confidence interval, 2.49–19.30); P<0.001]. Our results demonstrate that A-FABP is closely associated with HF, and raise the possibility that increased A-FABP may be causally related to the pathogenesis of heart dysfunction in humans.
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Research Article|
September 26 2012
Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure
Mingya Liu
;
Mingya Liu
1
*Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China
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Mi Zhou
;
Mi Zhou
1
†Department of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China
‡Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus; Shanghai Clinical Center for Diabetes, Shanghai, People's Republic of China
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Yuqian Bao
;
Yuqian Bao
‡Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus; Shanghai Clinical Center for Diabetes, Shanghai, People's Republic of China
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Zhiyong Xu
;
Zhiyong Xu
*Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China
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Huating Li
;
Huating Li
‡Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus; Shanghai Clinical Center for Diabetes, Shanghai, People's Republic of China
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Hao Zhang
;
Hao Zhang
*Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China
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Wei Zhu
;
Wei Zhu
*Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China
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Jialiang Zhang
;
Jialiang Zhang
§Department of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China
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Aimin Xu
;
Aimin Xu
§Department of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China
∥Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, People's Republic of China
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Meng Wei
;
*Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China
Correspondence: Professor Weiping Jia (email wpjia@sjtu.edu.cn) or Dr Meng Wei (email mrweei@medmail.com.cn).
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Weiping Jia
‡Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus; Shanghai Clinical Center for Diabetes, Shanghai, People's Republic of China
Correspondence: Professor Weiping Jia (email wpjia@sjtu.edu.cn) or Dr Meng Wei (email mrweei@medmail.com.cn).
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Clin Sci (Lond) (2013) 124 (2): 115–122.
Article history
Received:
January 03 2012
Revision Received:
August 03 2012
Accepted:
August 20 2012
Accepted Manuscript online:
September 26 2012
Citation
Mingya Liu, Mi Zhou, Yuqian Bao, Zhiyong Xu, Huating Li, Hao Zhang, Wei Zhu, Jialiang Zhang, Aimin Xu, Meng Wei, Weiping Jia; Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure. Clin Sci (Lond) 1 January 2013; 124 (2): 115–122. doi: https://doi.org/10.1042/CS20120004
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