UA (uric acid) is the final product of purine metabolism in humans and is implicated in many disease conditions. Sustained hyperuricaemia has putative adverse roles in cardiovascular diseases. Despite strong evidence emerging from large epidemiological studies supporting the hypothesis that UA independently influences cardiovascular disease outcomes and mortality, a causal role is yet to be established. Serum UA is also considered as a useful biomarker for mortality in high-risk patients with acute coronary syndromes, heart failure and hypertension and in patients with Type 2 diabetes mellitus. Post-hoc analyses of clinical trial data suggest beneficial effects of reducing serum UA. However, these findings are inconclusive and are only hypothesis-generating. In the present issue of Clinical Science, Ndrepepa and co-workers have investigated the prognostic role of UA in high-risk Type 2 diabetic patients with established coronary artery disease in predicting 1-year survival and cardiovascular mortality. These results support the independent role of serum UA in predicting survival in Type 2 diabetic patients. However, long-term follow-up studies are required with serial UA measurement to establish the time-dependent association of UA with mortality outcomes.
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Commentary| November 05 2012
Does uric acid qualify as an independent risk factor for cardiovascular mortality?
*Centre for Chronic Disease Control, New Delhi 110070, India
†Public Health Foundation of India, New Delhi 110070, India
‡Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, U.K.
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Publisher: Portland Press Ltd
Received: September 25 2012
Revision Received: October 08 2012
Accepted: October 09 2012
Accepted Manuscript online: October 09 2012
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2013 Biochemical Society
Panniyammakal Jeemon, Dorairaj Prabhakaran; Does uric acid qualify as an independent risk factor for cardiovascular mortality?. Clin Sci (Lond) 1 February 2013; 124 (4): 255–257. doi: https://doi.org/10.1042/CS20120524
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