Asthma is heterogeneous with respect to clinical presentation, underlying disease mechanisms and response to existing drugs making tailored therapy desirable. Pharmacogenetics, the study of the influence of genetic polymorphisms on drug efficacy and/or adverse effects, is relatively advanced in asthma with replicated genetic associations identified in the main drug classes. In the present issue of Clinical Science, Lipworth and co-workers report a proof-of-concept study and demonstrate that, in asthmatic children carrying the β2-adrenergic receptor gene Arg16 polymorphism, a combination of corticosteroid plus leukotriene receptor antagonist provides superior asthma control (e.g. quality of life scores) compared with corticosteroid plus a long-acting β2-adrenergic receptor agonist as add-on therapy. The basis of these observations is well founded, as it has been demonstrated previously that the Arg16 polymorphism may confer an increased risk of exacerbation following prolonged β2-adrenergic receptor agonist use. These results suggest Gly16Arg genotyping in Caucasian asthma patients may have a role in the clinical management of asthma by influencing the decision of which add-on therapy to prescribe; however, larger studies are required to provide definitive conclusions regarding the clinical utility of this approach.
Skip Nav Destination
Commentary| January 08 2013
A tailored approach to asthma management: Arg16 holds the key?
1Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, U.K.
Correspondence: Dr Ian Sayers (email email@example.com)
Search for other works by this author on:
Clin Sci (Lond) (2013) 124 (8): 517–519.
November 30 2012
December 03 2012
Accepted Manuscript online:
December 03 2012
A commentary has been published: Tailored second-line therapy in asthmatic children with the Arg16 genotype
Ian Sayers; A tailored approach to asthma management: Arg16 holds the key?. Clin Sci (Lond) 1 April 2013; 124 (8): 517–519. doi: https://doi.org/10.1042/CS20120640
Download citation file:
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your InstitutionSign in via your Institution
Get Access To This Article
Buy This Article